Pharma Excipients
Plasticizer
Formulation and Characterization of Buccal Films Containing Valsartan with Additional Support from…
The present study was aimed to the development and characterization of valsartan-containing buccal films with an introduction to a novel technique of image analysis. Visual inspection of the film provided a wealth of information that was difficult to quantify objectively. The obtained images of the…
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Hydrophilic High Drug-Loaded 3D Printed Gastroretentive System with Robust Release Kinetics
Three-dimensional printing (3DP) technology enables an important improvement in the design of new drug delivery systems, such as gastroretentive floating tablets. These systems show a better temporal and spatial control of the drug release and can be customized based on individual therapeutic needs.…
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Development of 3D Printed Multi-Layered Orodispersible Films with Porous Structure Applicable as a…
The direct tailoring of the size, composition, or number of layers belongs to the advantages of 3D printing employment in producing orodispersible films (ODFs) compared to the frequently utilized solvent casting method. This study aimed to produce porous ODFs as a substrate for medicated ink…
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Development and bioequivalence of 3D-printed medication at the point-of-care: bridging the gap…
Personalized medicine is currently hampered by the lack of flexible drug formulations. Especially for pediatric patients, manual compounding of personalized drug formulations by pharmacists is required. 3D printing of medicines, which enables small-scale manufacturing at the point-of-care, can…
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Microencapsulation by a Spray Drying Approach to Produce Innovative Probiotics-Based Products…
Recently, there has been a growing interest in producing functional foods containing encapsulated probiotic bacteria due to their positive effects on human health. According to their perceived health benefits, probiotics have been incorporated into a range of dairy products, but the current major…
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Development of multifunctional drug delivery system via hot-melt extrusion paired with fused…
The model of core–shell structured tablets is gaining increased interest due to its advantages in controlled-release and combinational drug delivery. Through the encapsulation of the drug by the outer shell, this model exhibits huge potential for reduced administration frequency, improved…
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SEDEX—Self-Emulsifying Delivery Via Hot Melt Extrusion: A Continuous Pilot-Scale Feasibility Study
The aim of this study was to develop a continuous pilot-scale solidification and characterization of self-emulsifying drug delivery systems (SEDDSs) via hot melt extrusion (HME) using Soluplus® and Kollidon® VA-64. First, an oil-binding capacity study was performed to estimate the maximal amount of…
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The effects of surfactants on the performance of polymer-based microwave-induced in situ…
Microwave-induced in situ amorphization is a novel technology for preparing amorphous solid dispersions (ASDs) to address the challenges of their long-term physical stability and downstream processing. To date, only few types of dielectric materials have been reported for microwave-induced in situ …
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Novel Approach to Pharmaceutical 3D-Printing Omitting the Need for Filament—Investigation of…
The utilized 3D printhead employs an innovative hot-melt extrusion (HME) design approach being fed by drug-loaded polymer granules and making filament strands obsolete. Oscillatory rheology is a key tool for understanding the behavior of a polymer melt in extrusion processes. In this study, small…
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Formulation Strategies to Improve the Stability and Handling of Oral Solid Dosage Forms of Highly…
Highly hygroscopic pharmaceutical and nutraceutical solids are prone to significant changes in their physicochemical properties due to chemical degradation and/or solid-state transition, resulting in adverse effects on their therapeutic performances and shelf life. Moisture absorption also leads to…
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