MIGLYOL® 812 N & IMWITOR® 742 – Product Spotlights
We invite you to read the below product spotlights of IOI Oleochemicals.
IMWITOR® 742
Chemical Description / Monograph Name:
- Glyceryl Mono and Dicaprylocapapate according to Ch.P.;
- Registration number: F20220000443
- Glycerol Monocaprylocaprate, Type I, according to Ph. Eur. also available as CEP-grade: CEP 2021-199
- Glyceryl Mono- and Dicaprylocaprate, USP-NF
Description:
IMWITOR® 742 is a partial glyceride of fully saturated caprylic and capric acid, based on plant-based raw materials, containing not less than 65 % of surface-active mono- and diglycerides. Typical dosing recommendations between 3-15 %.
FUNCTIONALITIES
- Drug Carrier
- Solubilizer
- Bioavailability Booster
- Co-Emulsifier O/W
- Defoamer
KEY FEATURES
- Co-Emulsifier and Bioavailability Booster for poorly water-soluble drugs
- Defoaming Agent
- Can incorporate up to 10% of water
- Very stable against oxidation
TYPICAL USES / DOSAGE FORMS
- Capsules
- Topicals
- Aerosols
PHYSICO-CHEMICAL PROPERTIES /
APPEARANCE
- Liquid to pasty-solid
- Melting point °C: ~ 25
- HLB value: 5 – 6
IMWITOR® 742 – OXIDATIVE STABILITY
The bioavailability enhancing property of IMWITOR® 742:
- Content of medium-chain fatty acids has the ability to solubilize lipophilic compounds
- In the intestinal lumen IMWITOR® 742 can form micelles incorporating poorly soluble actives, increasing their absorption concentration
- Enhanced permeability of the intestinal epithelium; due to their surfactant property, transport across intestinal barrier is improved
- Lymphatic absorption: Medium chain fatty acids are known to be preferentially absorbed into the lymphatic systems, bypassing the liver and potentially increasing bioavailability
- IMWITOR® 742 may increase the surface area available for absorption by dispersing the poorly soluble active into smaller particles and droplets, supporting the interaction with absorptive surfaces in the intestine
TYPICAL PROPERTIES AND VALUES
MIGLYOL® 812 N
Chemical Description / Monograph Name:
- Ch.P.: Medium-Chain Triglycerides, NMPA Registration: F20230000391
- Ph. Eur. / B.P. (current version): Triglycerides, Medium-Chain
- USP (current version): Medium-Chain Triglycerides
- MIGLYOL® 812 N also available as API Grade: NMPA registration Y20190009085; CEP R1-CEP 2012-410
Description:
MIGLYOL® 812 N is a triglyceride ester of saturated caprylic and capric fatty acids, made from plant-based raw materials. MIGLYOL® 812 N is a clear, virtually colorless, low viscosity liquid with a neutral odor and taste.
FUNCTIONALITIES
- Drug Carrier
- Solubilizer
- Emollient
- Lubricant
KEY FEATURES
- Neutral, Penetration Enhancer, Drug Carrier and Emollient
- Made from renewable, vegetable raw materials
- Excellent stability against thermal and oxidative stress
- Low impurity profile for improved drug quality,
also available as API-Grade
TYPICAL USES / DOSAGE FORMS
- Capsules
- Topicals
- Injectables
- Oral liquids
PHYSICO-CHEMICAL PROPERTIES /
APPEARANCE
- Oily liquid
- Viscosity mPa*s 20 °C: ~30
See the full brochure on “MIGLYOL® 812 N & IMWITOR® 742“ here
(click the picture to download the brochure)
Source: IOI Oleochemicals website https://www.ioioleo.de, brochure “MIGLYOL® 812 N & IMWITOR® 742”