Benecel K100LV PH PRM

Description

Benecel hypromellose (HPMC)

Benecel™ products are high purity, water-souble, nonionic cellulose ethers.  Benecel™ hypromellose (hydroxypropyl-methylcellulose or HPMC) is a versatile excipient with a variety of applications.  HPMC is the most widely used polymer in hydrophilic matrix systems with widespread use in controlled-release dosage forms.  The Benecel™ family of pharmaceutical products, including Benecel™ XR and XRF HPMC, custom grades of Benecel™ HPMC, and Benecel™ DC HPMC, provides a full portfolio to support the controlled release of a broad range of APIs and manufacturing processes.

Benecel™ XR and XRF HPMC grades:

Benecel™ XR and XRF are high-viscosity grades of HPMC with optimized polymer structure and particle morphology for use in matrix controlled-release systems.

Features and Benefits:

– Optimized polymer structure and particle morphology
– Consistent particle size distribution and bulk density
– Enhanced compactibility at high tableting speeds vs standard grades
– Fine particle size grades available (XRF)

Custom Grades of HPMC for Controlled Release:

Achieving a desired drug-release profile has traditionally involved blends of different molecular weights of particular polymers. Blending, however, can increase release-profile variability. Custom grades of Benecel™ HPMC were developed to obviate the need for blending and offer a potential solution to the problem of dissolution variability.

Features and Benefits:

– Increase predictability and reproducibility of drug release profiles
– Decrease research and development time needed to optimize blend ratio
– Decrease manufacturing time- no need to blend and manage multiple raw materials
– Opportunity to develop custom excipients