IMWITOR® 742

Description

Penetration enhancer, solvent, defoaming agent in effervescent tablets.

Chemical Description / Monograph Name:

• Glyceryl Mono and Dicaprylocapapate according to Ch.P.;
• Registration number: F20220000443
• Glycerol Monocaprylocaprate, Type I, according to Ph. Eur. also available as CEP-grade: CEP 2021-199
• Glyceryl Mono- and Dicaprylocaprate, USP-NF

Description:

IMWITOR® 742 is a partial glyceride of fully saturated caprylic and capric acid, based on plant-based raw materials, containing not less than 65 % of surface-active mono- and diglycerides. Typical dosing recommendations between 3-15 %.

The bioavailability enhancing property of IMWITOR® 742:

• Content of medium-chain fatty acids has the ability to solubilize lipophilic compounds
• In the intestinal lumen IMWITOR® 742 can form micelles incorporating poorly soluble actives, increasing their absorption concentration
• Enhanced permeability of the intestinal epithelium; due to their surfactant property, transport across intestinal barrier is improved
• Lymphatic absorption: Medium chain fatty acids are known to be preferentially absorbed into the lymphatic systems, bypassing the liver and potentially increasing bioavailability
• IMWITOR® 742 may increase the surface area available for absorption by dispersing the poorly soluble active into smaller particles and droplets, supporting the interaction with absorptive surfaces in the intestine