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IMWITOR® 742

IOI Oleo Topical

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Description

Penetration enhancer, solvent, defoaming agent in effervescent tablets.

Chemical Description / Monograph Name:

  • Glyceryl Mono and Dicaprylocapapate according to Ch.P.;
  • Registration number: F20220000443
  • Glycerol Monocaprylocaprate, Type I, according to Ph. Eur. also available as CEP-grade: CEP 2021-199
  • Glyceryl Mono- and Dicaprylocaprate, USP-NF

Description:

IMWITOR® 742 is a partial glyceride of fully saturated caprylic and capric acid, based on plant-based raw materials, containing not less than 65 % of surface-active mono- and diglycerides. Typical dosing recommendations between 3-15 %.

FUNCTIONALITIES

  • Drug Carrier
  • Solubilizer
  • Bioavailability Booster
  • Co-Emulsifier O/W
  • Defoamer

KEY FEATURES

  • Co-Emulsifier and Bioavailability Booster for poorly water-soluble drugs
  • Defoaming Agent
  • Can incorporate up to 10% of water
  • Very stable against oxidation

TYPICAL USES / DOSAGE FORMS

  • Capsules
  • Topicals
  • Aerosols

PHYSICO-CHEMICAL PROPERTIES /
APPEARANCE

  • Liquid to pasty-solid
  • Melting point °C: ~ 25
  • HLB value: 5 – 6

The bioavailability enhancing property of IMWITOR® 742:

  • Content of medium-chain fatty acids has the ability to solubilize lipophilic compounds
  • In the intestinal lumen IMWITOR® 742 can form micelles incorporating poorly soluble actives, increasing their absorption concentration
  • Enhanced permeability of the intestinal epithelium; due to their surfactant property, transport across intestinal barrier is improved
  • Lymphatic absorption: Medium chain fatty acids are known to be preferentially absorbed into the lymphatic systems, bypassing the liver and potentially increasing bioavailability
  • IMWITOR® 742 may increase the surface area available for absorption by dispersing the poorly soluble active into smaller particles and droplets, supporting the interaction with absorptive surfaces in the intestine

 

Additional information

Manufacturer

IOI Oleo
Quality

Ph.Eur., USP
Composition

Glycerolester of caprylic and capric acid
Dosage Form

Capsules, Topical
Function

Co-Emulsifier, defoamer, penetration/absorption enhancer
Synonym

Glycerol Caprylate/Caprate
Technical Name

Glycerol Caprylate/Caprate
Compendial Name

Glycerol Monocaprylocaprate, Type I

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