Kolliphor® P 188

Description

Flexible excipient to overcome a wide range of pharmaceutical challenges that provide formulators with increased efficiency and added functionality.

Kolliphor^® P 188 is an poloxamer that enables and enhances a wide range of functional applications. For instant and modified release applications, Kolliphor^® P 188 can act as a stabilizer in oral suspensions. In formulations that include poorly soluble actives, Kolliphor^® P 188 can improve solubility, absorption and bioavailability. Corresponding dosage forms can then be processed by melting or granulation. Kolliphor^® P 188 serves as a plasticizing agent, a solubilizer and an emulsifier, supporting both solid and liquid dispersions, as well as emulsions and micro-emulsions. Kolliphor^® P 188 can also act as a co-emulsifier in creams and emulsions for skin delivery applications.

Kolliphor^® P 188 can be used as an emulsifier and solubilizer, as a dispersing and wetting agent for solid dispersions and also to improve solubility, absorption and bioavailability of poorly soluble actives. It also is utilized as a co-emulsifier in creams, emulsions and as a suspension stabilizer and tablet lubricant. As dissolution enhancer, lubricant and wetting agent it is particularly suitable for wet granulation.

• HLB value >24
• It used as wetting agents, as emulsifiers and solubilizers
• It improves the solubility, abosoption and bioavailabiity of low-solubility actives
• Aqueous solution containing more than 20% concentraion are themoreversible viscosity
• Also used for hot-melt and spray-drying processes
• Poloxamers are non-ionic and less irritating upon appliaiton