Kolliphor® P407

Description

A polymeric multi-talent suitable for a large variety of applications, i.e. as thickening agent and gel former and as a co-emulsifier and viscosity enhancer in creams and liquid emulsions.

Kolliphor^® P 407 is used primarily as thickening agent and gel former, as well as co-emulsifier and consistency enhancer in creams and liquid emulsions. For certain active substances such as nifedipine, naproxen and fenticonazole as well as for essential oils in pharmaceutical formulations Kolliphor^® P 407 is also used as a polymeric solubilizer. In solid dispersions Kolliphor^® P 407 can be used in physical mixing, melt granulation, spray drying and hot melt extrusion processes. Moreover, Kolliphor^® P 407 is suitable for the formulation of active substances that show reduced solubility as well as chemical stability as a result of neutralization of gel formulations. Thanks to its ability to affect viscosity, it may also be used as stabilizer for topically administered suspensions and is used in tooth-pastes, gargles and mouthwashes. As dissolution enhancer, lubricant & wetting agent particularly Kolliphor® P 407 is specifically suitable for wet granulation processes.

• HLB value between 18-23
• It is primarily used as thickening agents and gel formers but also as wetting agents, as emulsifiers and solubilizers
• It shows characteristic property of thermoreversible gelation upon cooling or heating