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Kolliwax® S Fine

Kolliwax® from BASF

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Description

Used for various oral solid as well as semi-solid dosage forms: It can be used as a lubricant in oral dosage forms, matrix forming agent in sustained-release dosage forms, emulsifying and solubilizing agent in topical formulations and hardening agent in glycerin suppositories. Kolliwax® S Fine is particularly suitable for sensitive APIs.

Why choose Kolliwax® S Fine?

  • Fully approved, pharmaceutical-grade excipient – for your peace of mind
  • Compatible to a large number of actives
  • Guaranteed performance across a wide variety of applications
  • Particularly suitable for sensitive APIs
  • Effective alternative to magnesium stearate as lubricant
  • No metallic taste development

Major Applications of Kolliwax® S Fine

Lubricant: Lubricants prevent ingredients from clumping together and from sticking to the tablet punches or capsule filling machine. Lubricants also ensure that tablet formulation and ejection can occur with low friction. Common minerals like silica or talk, and fats, i.e. vegetable stearin, magnesium stearate or stearic acid are the most frequently used lubricants in tablets or hard gelatin capsules. Lubricants are added in small quantities to tablet and capsule formulations to improve certain processing characteristics.

In tablet formulations, Kolliwax® S Fine can be used as a lubricant as an effective alternative to magnesium stearate. Stearic acid is compatible to a large number of actives and does not provide a metallic taste. When used as lubricant Kolliwax® S Fine is blended to granular phase. The selection of the grade depends on formulation properties.

For film coating applications, Kolliwax® S Fine can be dispersed into hot (~60 C) aqueous solutions of hydroxypropoylmethylcellulose (HPMC). MCC can be added to further reduce water vapor transmission rate of the film. As a matrix former in sustained release tablets the use of 8-20% of Kolliwax® S Fine is recommended.

Film coatings: Kolliwax® S Fine can also be used as moisture protective component for coating films together with hydroxypropoylmethylcellulose (HPMC) and microcrystalline cellulose (MCC).

In combination with Kollicoat® SR 30 D, Kolliwax® S Fine creates sustained release profiles.

Emulsions: Kolliwax® S Fine can be used as a consistency factor and co-emulsifier in topical pharmaceutical applications. The typical concentration in emulsions and creams is about 1-5%. As a structure-building consistency factor with dry feel it forms a crystalline barrier on skin.

Suppository masses: Suppository formulations containing high amount of glycerol can be hardened by the addition of Kolliwax® S Fine.

Softgel formulations: For softgel formulations Kolliwax® S Fine can be used as emulsifying, viscosity enhancer and solubilizing agent or as solid lubricant for capsules shells.

Additional information

Manufacturer

BASF
Quality

JP, Ph.Eur., USP/NF
Dosage Form

Capsules, Creams, emulsion, gels, Lotions, Tablets
Function

Co-Emulsifier, Direct compression, Lubricant, plasticizer, Pore former, wet granulation
Technical Name

Fatty acids, palmitic acid, Stearic acid
Cas-No

67701-03-5
Einecs

266-928-5

Documents and Links

BASF Product Overview

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