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PharSQ® Spheres CM XL





PharSQ® Spheres CM are unique starter pellets, made of 80 percent anhydrous dibasic calcium phosphate and 20 percent microcrystalline cellulose. PharSQ® Spheres CM exhibit many distinct advantages, such as enhanced stability of the API, reduced moisture uptake or significitantly reduced electrostatic charges during the coating process.

Available in five different sizes to meet various customer needs.

Our newest solution for multiparticulates

With PharSQ® Spheres CM we offer unique calcium-phosphate based starter pellets for controlled release applications opening up new opportunities to our partners.

Many advantages for our customer

PharSQ® Spheres CM are small beads onto which the drug manufacturer can load the desired active ingredient. The almost perfectly round pellets have a diameter of only 0.1 to 1 millimeter depending on the product grade. The use is versatile, from filling into hard capsules or sachets to compression into tablets.

The unique characteristic of PharSQ® Spheres CM supports the loading of active ingredient to the desired dosage, which increases the safety of the drug. Through a combination of differently coated spheres the controlled release of the active ingredient can be optimized: to the targeted place in the digestive tract over the right period of time. In this way, the effectof medicines can be precisely adjusted to the actual needs.

During production of PharSQ® SpheresCM no organic solvent is used. Consequently, there is no risk of presence of organic volatile residuals in the final product.

Due to their very low moisture content, PharSQ® Spheres CM can be safely used with moisture sensitive drug substances, which enhance their stability. Due to the comparatively high density of PharSQ® Spheres CM tablet or capsule size can be reduced – a substantial benefit particularly for people with difficulty swallowing.

Composition: 80% dibasic calcium phosphate anhydrous (NF/USP, Ph.Eur., JP) and 20% microcrystalline cellulose (NF/USP, Ph.Eur., JP)

Assay of dibasic calcium phosphate (%): 75.0 – 85.0

pH: neutral

Loss on Drying (105°C/3h): < 1%

Bulk density (g/L): > 1.000

Particle size (μm): 850 – 1000

Equivalent to U.S. Mesh: 20 – 18

Common application: Capsule, Sachet

Additional information




JP, Ph.Eur., USP/NF


7757-93-9, 9004-34-6




Mixture of 80% dibasic calcium phosphate anhydrous and 20% microcrystalline cellulose

Dosage Form

Capsule, Sachets, Tablets


Drug Carrier

Compendial Name

Anhydrous Dibasic Calcium Phosphate, Microcrystalline Cellulose

Documents and Links

Budenheim product brochure


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