PRUV®

Description

Sodium Stearyl Fumarate

PRUV® is a tablet lubricant designed for formulations in which other lubricants lead to formulation and/or manufacturing challenges. As opposed to the frequently used lubricant, magnesium stearate, PRUV® offers the following advantages:

• High degree of API compatibility*
• Robustness to over-lubrication
• No adverse effect on bioavailability
• Improved appearance of effervescent solutions.
• PRUV® helps to accelerate product development and is particularly well suited for high-speed direct compression of tablets.

*Reported API incompatibilities with magnesium stearate include: Azathioprin, Cefaclor, Cilazapril, Clopidogrelacetate, Dicofenac, Fosinopril, Ibuprofen, Ketorolac, Levofloxacin, Nifedipine, Omeprazole, Ramipril, and Trandolapril.

Benefits:

• Improved drug stability
• Faster dissolution rates
• Harder tablets
• Protection from over-blending
• Faster formulation development and scale-up
• Enhanced lubrication efficiency