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L-HPC (low-substituted hydroxypropyl cellulose NF, JP, EP) was developed by Shin-Etsu and first approved in 1977 as a disintegrant for tablets in Japan. New grades were developed during the last years in order to cover the needs for our customer having best solutions for individual applications.
As example, LH-B1 was launched in 2002, a non fibrous grade, recommended as dispersing aid for capsule filling. In addition to the conventional grades (LH-), NBD- grades which have improved characteristics such as particle shape and compressibility were introduced in 2011.
L-HPC is a non-ionic multi-functional excipient based on a cellulose backbone combined with a low amount of hydroxypropopyl groups.
Thus, L-HPC is not soluble in water but showing swelling properties in this media.
Typical applications of L-HPC are anti-capping for tableting process, binder and disintegrant, stability enhancer of solid dosage forms. Several grades are available (see the table below) depending on the final application, focusing on the most common oral dosage forms: tablets, pellets and capsules.
| Manufacturer |
Shin-Etsu |
|---|---|
| Quantity 1 |
100gr |
| Composition |
cellulose, hydroxypropopyl groups, low-substituted hydroxypropyl cellulose |
| Dosage Form |
Capsule, Oral, Pellets, Tablets |
| Function |
Binder, Disintegrant, Continuous Manufacturing (CM) for Oral Solid Dosage Form (OSD), Dissolution improvement for wet granulation, non-ionic multi-functional excipient |
| Quality |
NF, EP, JP |
