VIVAPUR® MCG 581 P

Description

VIVAPUR^® MCG is a synergistic, co-processed composite consisting of microcrystalline cellulose (MCC) and sodium carboxymethylcellulose (Na-CMC). It is a unique suspending and emulsifying agent, which facilitates a wide range of liquid dosage forms. Due to its extraordinary stabilizing mechanism, VIVAPUR^® MCG can be used with a broad variety of active pharmaceutical ingredients (APIs), offering the opportunity for new applications and line extensions for existing products.

VIVAPUR^® MCG is a free flowing powder. After activation, MCG builds an opaque-white dispersion which masks insoluble particles, giving the suspension a homogenous appearance. The dispersed VIVAPUR^® MCG is distinguished by an odorless and tasteless, smooth but not slimy mouth feel, and handles flavors well. Upon agitation, MCG dispersions show a time-dependent decrease in viscosity and become liquid. A complete, also time-dependent, regeneration of the viscosity takes place during a subsequent rest period. This thixotropic behavior allows:

• Outstanding sprayability of nasal sprays
• Effortless dosing through drenches and dispensers
• Accurate dosage of oral suspensions
• Hassle-free handling of activated gel
• Ideal pumpability
• Smooth and pleasant swallowing without problems
• Excellent content uniformity

VIVAPUR^® MCG is used as a suspending agent, emulsifier, and thickener for:

• Oral suspensions
• Veterinary drenches
• Nasal sprays
• Reconstitutable powders
• Gels, creams, and lotions

Benefits:

• Easy handling of dry powder
• Heat stability
• Compatibility with a wide range of ingredients
• Stable over a wide pH range
• Safe for us in animal health products, pediatric suspensions, and nutraceuticals

Microcrystalline Cellulose and Carboxymethylcellulose Sodium, Ph. Eur., NF, E 460 (i) & E 466, FCC
	NaCMC (%)	Particle Size	Viscosity (mPa.s)	Main Application
VIVAPUR® MCG 581 P	8.3 – 13.8	>250 µm (60 mesh): max. 0.1% >75 µm (200 mesh): max. 35%	72 – 168 (1.2% solids)	For “ready-to-use” suspensions and emulsion prepared with high shear forces.
VIVAPUR® MCG 591 P	8.3 – 13.8	>250 µm (60 mesh): max. 0.1% >45 µm (325 mesh): max. 45%	39 – 91 (1.2% solids)
VIVAPUR® MCG 611 P	11.3 – 18.8	>250 µm (60 mesh): max. 0.1% >45 µm (325 mesh): max. 50%	50 – 118 (2.6% solids)	For reconstitutable dry suspensions.
VIVAPUR® MCG 811 P	11.3 – 18.8	>250 µm (60 mesh): max. 3%	2400 – 5600 (2.6% solids)	Highly effective dispersible cellulose grade for a variety of suspensions, emulsions, and spray applications.