Roller Compaction

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Abstract Purpose This study aims to develop an integrated control strategy using process analytical technology (PAT) and a quality by...

Abstract Roller compaction is often utilized as the first step to improve flow properties and homogeneity of pharmaceutical mixtures. Since...

Abstract Ribbon splitting, a phenomenon that can occur during the roller compaction operation used in dry granulation processes, can lead...

Abstract Pharmaceutical drug products in the form of tablets are produced via a series of manufacturing steps, transforming powder blends...

Abstract It is widely believed that compaction simulators can replicate the uniaxial compression process of a roller compactor. The correction...

Abstract Roller compaction/dry granulation (RC/DG) is a key process in pharmaceutical manufacturing for improving powder flowability, density, and segregation resistance....

Abstract We propose a novel approach for predicting the solid fraction after roller compaction processes. It is crucial to predict...

Abstract Process Analytical Technology (PAT) plays a crucial role in the design of today’s manufacturing lines as continuous manufacturing becomes...

Abstract Roller compaction is a key unit operation in a dry granulation line for pharmaceutical tablet manufacturing. During product development,...