The effect of excipient particle size on the reduction of compactibility after roller compaction

19. April 2022

Developing a robust roller compaction process can be challenging, due to the diversity in process parameters and material properties of...

Figure 1. scheme of roll compaction with D: roll diameter, N: nip width, S: gap width, T: ribbon thickness, α: nip angle.

Improving Process Understanding in Roll Compaction

12. February 2022

Roll compaction/ dry granulation is gaining importance. Numerous papers have been published and many attempts to model the process are available in...

Gerteis-Macro-Pactor®-flagship-pharma-roller-compactor

A Multi-variate Mathematical Model for Simulating the Granule Size Distribution in Roller Compaction-Milling Process

17. March 2021

Granule size distribution (GSD) is one of the critical quality attributes in the roller compaction (RC) process. Determination of GSD...

Compaction behavior of isomalt after roll compaction

8. May 2020

Isomalt is a polyol derived from sucrose. Advantages of this excipient are its sweet taste, which is supposed to allow...

A Mathematical Approach to Consider Solid Compressibility in the Compression of Pharmaceutical Powders

26. March 2020

In-die compression analysis is an effective method for the characterization of powder compressibility. However, physically unreasonable apparent solid fractions above...

An evaluation of the Johanson model for roller compaction process development for a high dose API

1. March 2020

Roller compaction (RC) is a dry granulation technique applied to improve the flow and compressibility of drug formulations. RC implementation...

Roller Compaction