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Silicon Dioxide
Investigation of Various Polymers for SLS 3D-Printing of Solid Oral Dosage Forms
Purpose
Selective laser sintering (SLS) is promising for printing oral dosage forms.
Print ranges for commonly used pharmaceutical polymers not yet established for additive manufactured medications.
Evaluate dedicated polymers for pharmaceutical applications.
Objectives…
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Study of Powder and Tableting Functionality Towards Evaluation and Characterisation of BARETab® PH…
Abstract
BARETab® PH is a multi-functional ready to use premixed, co-processed ingredient for direct compression (DC) formulations. It is a combination of selective, largely used excipients for DC. Direct compression is the most widely used tableting method because of the simple manufacturing…
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Preparation and Characterization of 3D-Printed Dose-Flexible Printlets of Tenofovir Disoproxil…
The aim of this work was to design pediatric-friendly, dose-flexible orally disintegrating drug delivery systems (printlets) of the antiviral drug tenofovir disoproxil fumarate (TDF) by selective laser sintering (SLS) for potential use in hospitals along with other antiviral drugs. In order to…
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Tableting of liquid form active ingredient with high performance liquid carrier
1. Introduction
Many liquid active ingredients are supplied in a soft-gel capsule form, because a soft gel capsule is easy to release control and can avoid formulation difficulties. However, it has serious weakness in stability, especially in humid environments; swallowability in the elder people,…
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HiCel™ Silicified Microcrystalline Cellulose, Versatile Excipient for Nutraceutical Herbal Tablet…
Abstract
Nutraceutical herbal medicine and supplements demand increases day by day. Herbal medicine normally contains lipids, protein, carbohydrate, vitamins, minerals and other necessary nutrients depending upon their emphases. Generally, all herbal extracts powder nature is fine poor flowable,…
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Development of extended-release formulations containing cyclobenzaprine based on physiologically…
The use of physiologically based biopharmaceutics modeling (PBBM) and bioequivalence safe space is increasingly common for immediate-release drug products. However, for extended-release (ER) formulations there are only a few examples of this application. In this study, we developed ER formulations…
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Impact of Raman Mapping Area and Intra-Tablet Homogeneity on the Accuracy of Sustained-Release…
This exploratory study investigated the minimum required Raman mapping area for predicting sustained-release tablet dissolution profiles based on intra-tablet homogeneity. The aim was to minimize scanning time while achieving reliable dissolution profile predictions. To construct the sample set, we…
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Modeling the Impact of Excipients Selection on Nitrosamine Formation towards Risk Mitigation
Abstract
Risk control for nitrosamine impurities in drug products is currently a major challenge in the industry. Nitrosamines can form during drug product manufacturing and storage through the reaction of nitrites with amine-containing APIs or impurities. The level of nitrites in excipients and…
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Unveiling Neusilin® US2’s Prowess: Resolving Oily API Challenges in Contrast to Other Common…
Neusilin® US2 by Fuji Chemical Industries is a synthetic, amorphous form of Magnesium Aluminometasilicate with a neutral pH that can be used in both direct compression and wet granulation of solid dosage forms. Oily APIs affect flowability, compressibility, and disintegration times, thereby posing…
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Development of a Discriminative Dissolution Method, Using In-Silico Tool for Hydrochlorothiazide and…
Hydrochlorothiazide (HTZ) and Valsartan (VAL) are poorly soluble drugs in BCS classes IV and II. This study aimed to develop a method to assess the dissolution profile of tablets containing HTZ (12.5 mg) and VAL (160 mg) as a fixed-dose combination, using in silico tools to evaluate products…
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