Solid Dispersion

Abstract This study presents a Quality by Design (QbD) strategy combined with Design of Experiments (DoE) to develop hybrid polymer–lipid hot-melt extruded (HME) formulations...

Amorphous Solid Dispersions See the new book, edited by Ioannis Nikolakakis, Ioannis Partheniadis. This book is intended for pharmaceutical formulation...

Amorphous Solid Dispersions See the new book, edited by Ioannis Nikolakakis, Ioannis Partheniadis. This book is intended for pharmaceutical formulation...

Abstract Sorafenib is an orally administered multikinase inhibitor whose clinical utility is limited by extremely low aqueous solubility and poor...

Abstract Purpose Azithromycin, a macrolide antibiotic, exhibits dissolution-limited oral absorption due to its poor solubility, and that affects its therapeutic...

Abstract Aim Efonidipine hydrochloride ethanolate (EHE), a BCS Class II calcium channel blocker, exhibits extremely poor aqueous solubility and undergoes...

Abstract Despite various attempts at solubility enhancement and advances in formulation technologies, improving the bioavailability of poorly water-soluble compounds remains...

Formulation of poorly soluble APIs remains one of the most persistent challenges in modern pharmaceutical development. With a growing number...

Abstract Amorphous solid dispersion (ASD) is a widely used formulation strategy for improving the apparent solubility and oral absorption of...

Abstract Roller compaction dry granulation is one of the pivotal dry granulation technologies in solid dosage form manufacturing, offering irreplaceable...