Mechanochemical Activation of Olanzapine in Mixed Solid Dispersions: Impact of Excipients on Release and Permeation Rates

12. April 2026

Abstract Background: The key parameters determining the bioavailability of an active pharmaceutical ingredient are its solubility/dissolution rate in physiological fluids...

Combined pre-formulation approach for the selection of naproxen-polymer-solvent candidates for the preparation of amorphous solid dispersion

6. April 2026

This poster has been presented at the 15th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology which took place in...

Development of amorphous solid dispersion of delamanid, an extremely water-insoluble drug, by hot melt extrusion applying acid-base supersolubilization (ABS) principle

3. April 2026

Abstract Delamanid, an antituberculosis drug used for multidrug-resistant tuberculosis, has extremely poor water solubility and a high melting point of...

Stabilization of supersaturation for enhanced oral absorption of a BCS II drug efonidipine hydrochloride: Eudragit® L100-55-based amorphous solid dispersions

22. March 2026

Abstract Supersaturation is a widely employed strategy to improve the oral bioavailability of poorly soluble drugs, but its application is...

Dissolution-Microdialysis predicts oral bioavailability from phospholipid-based amorphous solid dispersions

22. March 2026

Abstract Here, we report dissolution of aprepitant from three phospholipid-based amorphous solid dispersions (ASDs), namely binary ASDs containing drug and...

The influence of drug loading on dissolution behaviours and stability of surfactant-containing amorphous solid dispersions

9. March 2026

Abstract This study explores the impact of drug loading (DL) on the physical stability, dissolution performance, and micellisation behaviour of...

Double action of HPMCAS as a dry binder and precipitation inhibitor in ASD tablet formulations of nifedipine prepared by hot-melt extrusion

9. March 2026

Abstract Poor tablet hardness and drug re-crystallization are two common challenges of amorphous solid dispersion (ASD) formulations prepared with hot-melt...

Evaluation of Process Parameters in the Development of Ternary Ketoprofen Amorphous Solid Dispersions via Hot Melt Extrusion

7. March 2026

Abstract Background/Objectives: Poor aqueous solubility of active pharmaceutical ingredients (APIs) remains a critical barrier to effective oral formulation. This study...

Impact of disintegrants on the structure and disintegration of hydroxypropyl methylcellulose-based amorphous solid dispersion tablets

17. February 2026

Abstract Amorphous solid dispersion (ASD) is a widely adopted strategy to enhance the solubility of poorly water-soluble drugs. However, disintegration...

Curcumin amorphous solid dispersions formed by Eudragit EPO and hydroxypropyl methylcellulose E50 achieve superior analgesic effect

13. February 2026

Abstract Poor solubility of curcumin (Cur) has greatly limited its applications. To establish Cur amorphous solid dispersions (Cur ASDs) with...

Solid Dispersion