Solid Dispersion

Safe and Endogenous Compounds for Pharmaceutical Applications Phospholipids are ubiquitous, endogenous, and nutritional compounds. For pharmaceutical applications, phospholipids are safe...

This study reports the application of in situ stimulated Raman scattering (SRS) microscopy for real-time chemically-specific imaging of dynamic phase...

Abstract Over the last 15 years, a small number of paediatric artemisinin-based combination therapy products have been marketed. These included Riamet®...

Abstract Neratinib maleate (NM) used in the treatment of breast cancer, has a low and variable oral bioavailability due to...

Abstract Twenty-five years ago, Hancock and Parks asked a provocative question: “what is the true solubility advantage for amorphous pharmaceuticals?”...

Improving the solubility of poorly water-soluble drugs is essential for enhancing bioavailability, formulation flexibility and reducing patient-to-patient variability. The preparation...

Abstract Hot melt extrusion (HME) has been widely used as a continuous and highly flexible pharmaceutical manufacturing process for the...

Guanfacine (GFC) extended-release tablet (Intuniv®) is an effective non-stimulant medication prescribed for attention deficit hyperactivity disorder (ADHD), presenting limitations regarding...

High-shear (HS) melt granulation and hot melt extrusion (HME) were compared as perspective melt-based technologies for preparation of amorphous solid...

About 90% of active pharmaceutical ingredients (APIs) in the oral drug delivery system pipeline have poor aqueous solubility and low...