Dual-mechanism gastroretentive drug delivery system loaded with an amorphous solid dispersion prepared by hot-melt extrusion

6. March 2017

Abstract In the present study, we aimed to prepare a gastroretentive drug delivery system that would be both highly resistant...

Mucoadhesive amorphous solid dispersions for sustained release of poorly water soluble drugs

19. January 2017

19. January 2017 Abstract The oral delivery of mucoadhesive patches has been shown to enhance the absorption of large molecules...

Bioavailability enhancement of itraconazole-based solid dispersions produced by hot melt extrusion in the framework of the Three Rs rule

15. December 2016

15. December 2016 Abstract Solid dispersion formulations made of itraconazole (ITZ) and Soluplus® (polyethylene glycol, polyvinyl acetate and polyvinylcaprolactame-based graft...

Continuous Production of Itraconazole-based Solid Dispersions by Hot Melt Extrusion: Preformulation, Optimization and Design Space Determination

11. October 2016

The purpose of this work was to increase the solubility and the dissolution rate of itraconazole, which was chosen as...

A Self-microemulsifying Drug Delivery System (SMEDDS) for a Novel Medicative Compound Against Depression: a Preparation and Bioavailability Study in Rats.

8. February 2015

08. February 2015 AJS is the code name of an untitled novel medicative compound synthesized by the Tasly Holding...

Solid Dispersion