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The quantification of both polymer and drug during the dissolution of an amorphous solid dispersion (ASD) in aqueous media arouses...
Abstract Developing co-amorphous systems is an attractive strategy to improve the dissolution rate of poorly water-soluble drugs. Various co-formers have...
Solid oral controlled release formulations feature numerous clinical advantages for drug candidates with adequate solubility and dissolution rate. However, most...
Abstract The purpose of this study was to investigate improving solubility using hydrophilic/water-soluble polymers as β-Cyclodextrin and Plasdone K-30 in...
Pretomanid (PTM), an oral antibiotic used in the treatment of adults with pulmonary extensively drug-resistant, nonresponsive multidrug-resistant tuberculosis (MDR-TB). It...
Abstract Spray drying is used in the pharmaceutical industry for particle engineering of amorphous solid dispersions (ASDs). The particle size...
Abstract Purpose The study aimed to develop and optimize apremilast (APST) solid dispersion formulations using copovidone (Kollidon VA64) as the...
This study aims to improve the biopharmaceutical, mechanical, and tableting properties of a poorly soluble drug, ibuprofen (IBP), by preparing...
Abstract Forty-eight (48) drug products (DPs) containing amorphous solid dispersions (ASDs) have been approved by the U.S. Food and Drug...
Abstract Oral administration of a drug substance has become one of the most important drug delivery routes. In chronic diseases...
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