Solubility Enhancement

Abstract Oral drug delivery remains the preferred method of drug administration but due to poor solubility many active pharmaceutical ingredients...

Introduction Axitinib (AXT), a second-generation inhibitor of vascular endothelial growth factor receptors (VEGFR), is used in the treatment of advanced...

Abstract Amorphous solid dispersions (ASDs) are widely recognized for their potential to enhance the solubility of poorly water-soluble drugs, with...

Abstract This work reports on the first developed solid dispersed systems (SDSs) of nimesulide using technology of centrifugal fiber formation,...

Abstract Developing orally administered pediatric formulations presents significant challenges due to the unique characteristics of pediatric patients. Terbinafine hydrochloride (TER),...

Abstract Apigenin (APG), a bioactive flavonoid with promising therapeutic potential, suffers from poor water solubility, which limits its bioavailability. To...

Abstract Enzalutamide (ENZ), marketed under the brand name Xtandi® as a soft capsule, is an androgen receptor signaling inhibitor drug actively...

Abstract Background Ritonavir is an anti-retroviral protease inhibitor to treat HIV, AIDS infections. Methods The RN-SLNs were prepared by using...

Abstract Background: Curcumin and hesperetin are plant polyphenols known for their poor solubility. To address this limitation, we prepared amorphous PVP...

Abstract Micronization is frequently employed to increase the dissolution of poorly soluble drugs, but it easily led to powder aggregation...