Solubility Enhancement

KLK Kolb excipients, marketed under the Hedjuvan brand, are all produced at the Hedingen facility in Switzerland. These versatile excipients...

Abstract It is desirable but remains challenging to develop high drug load amorphous solid dispersions (ASDs) without compromising their quality...

Abstract Purpose: To improve the oral absorption of relugolix (RLGL), which has low oral bioavailability due to its low solubility...

Abstract Oral delivery of bedaquiline is the preferred route of drug delivery in the treatment of multidrug-resistant tuberculosis, although its...

Abstract Oral drug delivery remains the preferred method of drug administration but due to poor solubility many active pharmaceutical ingredients...

Introduction Axitinib (AXT), a second-generation inhibitor of vascular endothelial growth factor receptors (VEGFR), is used in the treatment of advanced...

Abstract Amorphous solid dispersions (ASDs) are widely recognized for their potential to enhance the solubility of poorly water-soluble drugs, with...

Abstract This work reports on the first developed solid dispersed systems (SDSs) of nimesulide using technology of centrifugal fiber formation,...

Abstract Developing orally administered pediatric formulations presents significant challenges due to the unique characteristics of pediatric patients. Terbinafine hydrochloride (TER),...

Abstract Apigenin (APG), a bioactive flavonoid with promising therapeutic potential, suffers from poor water solubility, which limits its bioavailability. To...