Solubility Enhancement

This study evaluates the in vivo mucoadhesive properties of thiolated cyclodextrins (CDs) with varying S-protection using polyethylene glycol (PEG) of...

Here we designed an optimized NLC for the transport of CLP, an antiplatelet molecule, and further probed its microstructure, cytotoxicity...

Abstract Mesoporous silica carriers are known to improve the solubility and bioavailability of poorly soluble Class II drugs. However, most...

Abstract The flavonoid hesperidin is a crucial, biologically active substance of great interest because of its polypharmacological properties and high...

Abstract This study developed a mucoadhesive self-nano emulsifying drug delivery system (SNEDDS) with synthesized acyl chitosan coating for enhancing oral...

Abstract Background The complex physicochemical properties of the lipids have considerable impact on the solubility and stability of the Lipid...

Abstract Genistein, a bioactive isoflavone, offers therapeutic potential but is hindered by poor water solubility, limiting its oral bioavailability. This...

Abstract This study developed a solid self-nanoemulsifying drug delivery system (S-SNEDDS) to improve the oral bioavailability of poorly soluble carvedilol...

Abstract Amorphous solid dispersion (ASD) is one of the most studied strategies for improving the dissolution performance of poorly water-soluble...

Abstract This study hypothesizes that phospholipid-based naturosoomal nanocarriers can significantly enhance the oral solubility and bioavailability of naringin (NARNs) by...