Solubility Enhancement

Abstract This study developed a mucoadhesive self-nano emulsifying drug delivery system (SNEDDS) with synthesized acyl chitosan coating for enhancing oral...

Abstract Background The complex physicochemical properties of the lipids have considerable impact on the solubility and stability of the Lipid...

Abstract Genistein, a bioactive isoflavone, offers therapeutic potential but is hindered by poor water solubility, limiting its oral bioavailability. This...

Abstract This study developed a solid self-nanoemulsifying drug delivery system (S-SNEDDS) to improve the oral bioavailability of poorly soluble carvedilol...

Abstract Amorphous solid dispersion (ASD) is one of the most studied strategies for improving the dissolution performance of poorly water-soluble...

Abstract This study hypothesizes that phospholipid-based naturosoomal nanocarriers can significantly enhance the oral solubility and bioavailability of naringin (NARNs) by...

KLK Kolb excipients, marketed under the Hedjuvan brand, are all produced at the Hedingen facility in Switzerland. These versatile excipients...

Abstract It is desirable but remains challenging to develop high drug load amorphous solid dispersions (ASDs) without compromising their quality...

Abstract Purpose: To improve the oral absorption of relugolix (RLGL), which has low oral bioavailability due to its low solubility...

Abstract Oral delivery of bedaquiline is the preferred route of drug delivery in the treatment of multidrug-resistant tuberculosis, although its...