Solubility Enhancement

In this study, we investigated the formulation of stable solid dispersions to enhance the bioavailability of olaparib (OLA), a therapeutic...

Abstract Amorphous solid dispersion (ASD) has emerged to be an outstanding strategy among multiple options available for improving solubility and...

Abstract Compaction pressure can induce an undesirable solid-state polymorphic transition in drugs, fragmentation, loss of coated pellet integrity, and the...

Abstract PROTACs, proteolysis targeting chimeras, are bifunctional molecules inducing protein degradation through a unique proximity-based mode of action. While offering...

This poster was presented at CRS 2024 in Bologna Introduction Parenteral formulations often contain higher concentrations of excipients than active...

SOLBIOTE (TM) – Injectable-grade Saccharide Excipients for Biopharmaceuticals Nagase Viita, the first company in the world to mass produce Trehalose, has...

Berberine is used in the treatment of metabolic syndrome and its low solubility and very poor oral bioavailability of berberine...

Abstract Self-emulsifying drug delivery systems (SEDDSs) represent a significant breakthrough in addressing bioavailability challenges by enhancing the solubilization of poorly...

Abstract The disadvantages of some conventional drugs, including their low bioavailability, poor targeting efficiency, and important side effects, have led...

Abstract Increasing the solubility of drugs is a recurrent objective of pharmaceutical research, and one of the most widespread strategies...