Solubility Enhancement

Abstract Neratinib maleate (NM) used in the treatment of breast cancer, has a low and variable oral bioavailability due to...

Abstract Twenty-five years ago, Hancock and Parks asked a provocative question: “what is the true solubility advantage for amorphous pharmaceuticals?”...

Abstract Herein, we present an elegant and simple method for significant improvement of eugenol water solubility using the polymers Soluplus® and...

Improving the solubility of poorly water-soluble drugs is essential for enhancing bioavailability, formulation flexibility and reducing patient-to-patient variability. The preparation...

EUDRAGIT® polymers can be used individually or in combination to match virtually any target release profile including immediate, delayed, sustained,...

Abstract Inflammatory Bowel Disease (IBD) is a chronic condition that affects approximately 1.6 million Americans. While current polyphenols for treating...

About 90% of active pharmaceutical ingredients (APIs) in the oral drug delivery system pipeline have poor aqueous solubility and low...

Multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB) continue as public health concerns. Inhaled drug therapy for TB has substantial...

Abstract Improvement in drug solubility is a major challenge for developing pharmaceutical products. It was demonstrated earlier that aqueous solubilities...

The phospholipids complexation technique is the best solubility enhancement technology, and as a result, many authors have successfully used it...