Efavirenz dissolution enhancement III: Colloid milling, pharmacokinetics and electronic tongue evaluation

3. January 2017

03. January 2017 Abstract Efavirenz (EFV), a non-nucleoside reverse transcriptase inhibitor (NNRTI), is part of first-line therapy for the treatment...

Oral hesperidin—Amorphization and improved dissolution properties by controlled loading onto porous silica

22. November 2016

22. November 2016 Abstract The oral bioavailability of poorly soluble drugs can be improved by amorphization generated by loading into...

Preparation and tableting of long-term stable amorphous rutin using porous silica

17. November 2016

17. November 2016 Abstract Amorphous state of drugs increases the oral bioavailability, but typically faces physical stability problems. Amorphous rutin...

Continuous Production of Itraconazole-based Solid Dispersions by Hot Melt Extrusion: Preformulation, Optimization and Design Space Determination

11. October 2016

The purpose of this work was to increase the solubility and the dissolution rate of itraconazole, which was chosen as...

Improving the granule strength of roller-compacted ibuprofen sodium for hot-melt coating processing

25. June 2016

25. June 2016 Abstract Solvent-free hot-melt coating processing is a novel and cost-efficient approach to manufacturing taste-masked multiparticulate systems. However,...

Non Mcc Polymer as a Pelletisation Aid: A Review

20. February 2016

20. February 2016 Extrusion spheronization is the widely used method by which the pellets are formulated. Pellets have certain advantages...

The central role of excipients in drug formulation

8. October 2015

Active substances are rarely administered alone. For example, levothyroxine, a synthetic form of the thyroid hormone, indicated in the treatment...

Syloid® XDP silica – New Application Note on Solid delivery of PEG drug solubilizers – Whitepaper

22. September 2015

22. September 2015 Syloid® XDP silica: Carrier for liquid drug solubilizers in solid dosage form. The solubility of poorly soluble...

Spray drying of nanoparticles to form fast dissolving glipizide – Article

15. July 2015

Poor water solubility of pharmaceutical candidates creates a big barrier to development and clinical applications. In this study, glipizide as...

Formulation and evaluation of multiparticulate drug delivery systems comprising telmisartan – Article

14. July 2015

14. July 2015 Telmisartan is poorly soluble in water, and the rate of dissolution, as well as bioavailability, is less....

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