Excipients Used in Oral Nanocarrier-Based Formulations
Chapter 10 „Excipients Used in Oral Nanocarrier-Based Formulations“ by Rajan Jog and Diane Burgess mentioned in the title is part of the Book:
Fundamentals of Nanoparticles – 1st Edition
Fundamentals of Nanoparticles: Classifications, Synthesis Methods, Properties and Characterization explores the nanoparticles and architecture of nanostructured materials being used today in a comprehensive, detailed manner. This book focuses primarily on the characterization, properties and synthesis of nanoscale materials, and is divided into three major parts. This is a valuable reference for materials scientists, and chemical and mechanical engineers working in R&D and academia, who want to learn more about how nanoparticles and nanomaterials are characterized and engineered.
Part one covers nanoparticles formation, self-assembly in the architecture nanostructures, types and classifications of nanoparticles, and signature physical and chemical properties, toxicity and regulations. Part two presents different ways to form nanometer particles, including bottom-up and top-down approaches, the classical and non-classical theories of nanoparticles formation and self-assembly, surface functionalization and other surface treatments to allow practical use. Part three covers characterization of nanoparticles and nanostructured materials, including the determination of size and shape, in addition to atomic and electronic structures and other important properties.
Excipients Used in Oral Nanocarrier-Based Formulations – Chapter 10
The focus of this book chapter is to provide a detailed understanding of the type, properties, advantages and limitations of excipients in an array of oral nanocarriers. Excipients typically used in oral nanocarriers include: emulsifiers, solubilizing agents, stabilizers, targeting ligands, polymers and lipids. Excipient properties that have a significant effect on the critical quality attributes of the various nanocarrier systems will be examined. The pros and cons of the excipients utilized in oral nanocarriers will be discussed. In addition, the safety aspects of excipients in oral nanocarriers and the current regulatory status of these excipients in various countries, will be discussed.
The chapter covers:
2.1 Oral Polymeric Nanoparticles
2.2 Oral Lipid Nanoparticles
2.3 Drug-Polymer Conjugates
2.4 Drug-Lipid Conjugates
2.5 Polymeric Micelles
2.6 Oral Liposomes
3 Safety of Excipients Through Oral Route
4 Regulatory Status of Excipients
5 Conclusions and Future Outlook
Editors: Abdel Salam Hamdy Makhlouf Ahmed Barhoum