Successful development of oral SEDDS: Screening of excipients from the industrial point of view

13. November 2018

Oral administration is the most accepted and favored route as various side effects such as fear, pain and risk of...

Differences of In Vivo absorption and In Vitro dissolution

Relationship between amorphous solid dispersion In Vivo absorption and In Vitro dissolution

10. November 2018

Enzalutamide is a fast crystallizing, hydrophobic compound that has solubility limited absorption in vivo. Given the low aqueous solubility of...

Chart about Inhibitory Effects of Excipients on P-Glycoprotein

Inhibitory Effects of Commonly Used Excipients on P-Glycoprotein in Vitro

5. November 2018

Pharmaceutical excipients are no longer considered inert and have been shown to influence the activity of metabolic enzymes and transporters,...

In vitro lipolysis test in lipid-based formulation development

29. October 2018

The lipolysis test is recommended during lipid-based formulation (LBF) development to evaluate whether the prototype formulations should be able to...

How milk works as a drug delivery system

The impact of digestion is essential to the understanding of milk as a drug delivery system for poorly water soluble drugs

27. October 2018

Milk has previously been considered as a potential lipid-based drug delivery system for poorly water soluble drugs but it has...

One-pager on the BASF PVP-based solubilizers

Interested why Kollidon® 12 PF / Kollidon® 17 PF are particularly suitable for parenteral applications?

26. October 2018

Did you know that Kollidon® 12 PF and Kollidon® 17 PF are highly suitable for injectable formulations? Kollidon® 12 PF/...

Introduction to pharmaceutical excipients – a video

23. October 2018

In this video Chris Moreton gives an interesting insight on pharmaceutical excipients.

Lecithin–chitosan–TPGS nanoparticles as nanocarriers of (−)-epicatechin enhanced its anticancer activity in breast cancer cells

18. October 2018

Natural compounds such as (−)-epicatechin show a variety of biological properties including anticancer activity. Nonetheless, (−)-epicatechin's therapeutic application is limited...

Soluplus solutions as thermothickening materials for topical drug delivery.

17. October 2018

Soluplus is a pharmaceutical excipient used primarily in the manufacture of solid dispersions. The polymer also exhibits interesting rheology in...

Chart of aggregation of itraconazole particles and the impact of polymers

Impact of polymers on the aggregation of wet-milled itraconazole particles and their dissolution from spray-dried nanocomposites

15. October 2018

We explore the impact of various polymers and their molecular weight on the stabilization of wet-milled suspensions of itraconazole (ITZ),...

Solubilizer