Pharma Excipients
Speciality Excipient
Development of A New Delivery System Based on Drug-Loadable Electrospun Nanofibers for Psoriasis…
Psoriasis is a chronic autoimmune systemic disease with an approximate incidence of 2%
worldwide; it is commonly characterized by squamous lesions on the skin that present the typical
pain, stinging, and bleeding associated with an inflammatory response. In this work, poly(methyl
vinyl…
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Current Developments in Excipient Science – Implication of Quantitative Selection of Each…
Implication of Quantitative Selection of Each Excipient in Product Development
Excipients’ role in designing different dosage forms does not require any introduction. These are the additives that are added to the formulation along with pharmacologically active substance. The main purpose of adding…
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Solid nanoparticles for oral antimicrobial drug delivery
Most microbial infectious diseases can be treated successfully with the remarkable array of antimicrobials current available; however, antimicrobial resistance, adverse effects, and the high cost of antimicrobials are crucial health challenges worldwide. One of the common efforts in addressing this…
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Fast Dissolving of Ferulic Acid via Electrospun Ternary Amorphous Composites Produced by a Coaxial…
Enhancing the dissolution of insoluble active ingredients comprises one of the most
important issues in the pharmaceutical and biomaterial fields. Here, a third generation solid
dispersion (3rd SD) of ferulic acid was designed and fabricated by a modified coaxial electrospinning
process.
A…
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Loading of Porous Functionalized Calcium Carbonate Microparticles
Accurate analysis of intraparticle distribution of substances within porous drug carriers is important to optimize loading and subsequent processing. Mercury intrusion porosimetry, a common technique used for characterization of porous materials, assumes cylindrical pore geometry, which may lead to…
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HiCel™ Silicified Microcrystalline Cellulose
HiCel™ is a versatile co-processed excipient with added-value to standard microcrystalline cellulose types. See this short video to get an overview of why you should consider HiCel™ in your formulation work:
Click here for more information on Sigachi´s excipients!
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The Effect of Molecular Properties on Active Ingredient Release from Electrospun Eudragit Fibers
The formation of nanoscale fibers from pH-sensitive polymers is a route which has been widely explored for targeted drug delivery. In particular, the Eudragit L100 and S100 families of polymers have received significant attention for this purpose.
However, while in some cases it is shown that…
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Homogenization of Amorphous Solid Dispersions Prepared by Electrospinning in Low-Dose Tablet…
Low-dose tablet formulations were produced with excellent homogeneity based on drug-loaded electrospun fibers prepared by single-needle as well as scaled-up electrospinning (SNES and HSES). Carvedilol (CAR), a BCS II class compound, served as the model drug while poly (vinylpyrrolidone-co-vinyl…
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Multifunctional oral delivery systems for enhanced bioavailability of therapeutic peptides/proteins
In last few years, therapeutic peptides/proteins are rapidly growing in drug market considering their higher efficiency and lower toxicity than chemical drugs. However, the administration of therapeutic peptides/proteins is mainly limited in parenteral approach. Oral therapy which was hampered by…
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Chitosan-Based Mucoadhesive Vaginal Tablets for Controlled Release of the Anti-HIV Drug Tenofovir
Vaginal microbicides have the potential to give women at high risk of contracting HIV the option of self-protection by preventing the sexual transmission of the virus. In this paper, mucoadhesive vaginal tablets based on chitosan, alone and in combination with pectin and locust bean gum, were…
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