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Stabilizer
Importance of β-cyclodextrin substitution level and type for solubilization and stabilization of…
This poster was presented at CRS 2024 in Bologna
Introduction
Parenteral formulations often contain higher concentrations of excipients than active ingredients. These excipients enhance safety, provide solubility, better stability, increase bioavailability, improve patient compliance, or generally…
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Risk-Based Approach for Defining Retest Dates for Active Pharmaceutical Ingredients and Excipients
Abstract
Drug substances and excipients must be stored in recommended storage conditions and should comply with their specifications during the retest period for their use in the manufacture of drug products. The ICH (International Council for Harmonization of Technical Requirements for…
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Optimizing Softgel Fill Formulation: Key Considerations
Softgel capsules are a popular dosage form for pharmaceuticals and supplements, offering benefits like improved bioavailability and ease of swallowing. However, creating effective softgel formulations, especially for suspensions (pastes), involves complex considerations. This article explores these…
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Exploring the potential of native and modified starch and starch nanocrystals in Pickering…
Abstract
Nanocrystals derived from organic particles, such as starch, can be produced through acid or enzymatic hydrolysis reactions to serve as stabilizers in Pickering emulsions. Starch nanocrystals (SNCs) offer the advantage of providing enhanced storage stability and controlled in vitro and …
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Quality Assesment and Stability Studies of Metronidazole Tablets Formulations Obtained via Crystallo…
Abstract
Stability studies are essential for assessing the quality, safety, and efficacy of pharmaceutical products, ensuring they maintain their properties over time. This study aimed to assess the stability of metronidazole tablets stored in a desiccator with charged silica gel following the…
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SOLBIOTE (TM)- Bringing Sustainable Solutions to Biopharmaceuticals
SOLBIOTE (TM) – Injectable-grade Saccharide Excipients for Biopharmaceuticals
Nagase Viita, the first company in the world to mass produce Trehalose, has launched a new product brand SOLBIOTE (TM). This brand features high-purity, low-endotoxin Trehalose (TREHALOSE SG) and Maltose (MALTOSE PH)…
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Unlocking the Potential of Softgel Capsules: Types and Formulations
Softgel capsules are a popular choice for delivering a wide range of compounds, from pharmaceuticals to nutritional supplements. Their versatility and efficacy hinge on the type of fill material used. Let's explore the three primary types of fills for softgel capsules: Single Oil or Oil Mixtures,…
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Stability of Free and Liposomal Encapsulated RNA on a Mucoadhesive PVA Polymer for Esophageal RNA…
Abstract
The development of RNA and oligonucleotide-based therapeutics is a longstanding goal and is currently gaining significant attention. Several RNA-based drugs are approved for clinical use. Others are under investigation or in preclinical trials. This study have initiated the development…
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Carrier Systems for Advanced Drug Delivery: Improving Drug Solubility/Bioavailability and…
Abstract
The disadvantages of some conventional drugs, including their low bioavailability, poor targeting efficiency, and important side effects, have led to the rational design of drug delivery systems. In particular, the introduction of drug delivery systems is a potential approach to enhance…
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Mucoadhesive aprepitant-loaded nanostructured lipid carriers containing sulfhydryl surfactant for…
The objective of the study was to design mucoadhesive drug-loaded nanostructured lipid carriers (NLCs) for enhancing the bioavailability of a model BCS Class IV drug aprepitant (APT). For this purpose, polyethoxylated surfactant (polyoxyethylene 20 oleyl ether) was thiolated, and mucoadhesive NLCs…
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