Browsing Category
Stabilizer
A comprehensive mechanistic investigation of factors affecting intestinal absorption and…
Abstract
Aim
Proteolysis targeting chimeras (PROTACs) exhibit a unique and promising pharmacology. However, this comes with molecular properties exceeding the ‘drug-like’ rule of five chemical space, which often limits gastrointestinal absorption. This in vivo study aimed to investigate the…
Read More...
Read More...
Optimizing Pharmaceutical Formulations: Strategies for Improving Stability and Minimizing Impurities
Pharma Excipients proudly present the new webinar with Roquette and Catalent:
Optimizing Pharmaceutical Formulations: Strategies for Improving Stability and Minimizing Impurities
About the Webinar:
Join Amit Chivate, Ph.D., MBA, Senior Area Marketing Manager for Greater…
Read More...
Read More...
Thermoresponsive engineered emulsions stabilised with branched copolymer surfactants for nasal drug…
Abstract
Novel branched copolymer surfactants (BCS) allow the formation of oil-in-water emulsions that exhibit a temperature-induced liquid-to-gel transition. If the temperature of this transition is between room and body temperature (ca 25 and 37 °C, respectively), then the emulsions form a gel in…
Read More...
Read More...
Enhanced Delivery of Posaconazole Using Novel Solid Self Nanoemulsifying Drug Delivery System: In…
Abstract
Purpose
Posaconazole (POS) is widely used as an antifungal agent effective against Candida infections. Because of its very low water and high fat solubility, it falls under the Biopharmaceutics Classification System (BCS) Class II. It showed considerable differences in absorption rates…
Read More...
Read More...
A recent update of water-soluble polymers in cyclodextrin-based formulations for mucosal drug…
Abstract
Cyclodextrins (CDs) play a crucial role in pharmaceutical formulations due to their unique ability to form inclusion complexes with a wide range of lipophilic drugs. Ternary complexes comprising CD, water-soluble polymer, and drug molecule have emerged as promising multicomponent to the…
Read More...
Read More...
New product – Kleptose F 7% – BETA CYCLODEXTRIN
Roquette presents a new product:
KLEPTOSE® F 7% - EXP β-cyclodextrin for oral dosage forms contains less than 7% of water. It is well suited for dry processing techniques, such as direct compression, where its low water content benefits moisture-sensitive APIs and formulations (e.g., ODTs,…
Read More...
Read More...
A design of experiment approach to identify the most stable composition of a ternary co-amorphous…
Abstract
Ternary co-amorphous systems, comprising a drug, a low molecular weight co-former, and a polymer, are a promising approach to address the solubility and stability challenges of poorly water-soluble drugs. However, it is unclear how the addition of a third component influences the stability…
Read More...
Read More...
Fabrication of lipid-modified drug nanocrystals loaded injectable hydrogel for breast cancer therapy
Abstract
The current study includes the design of soluplus stabilized, lipid-coated, and fucoidan-oleylamine conjugate modified paclitaxel nanocrystals. The nanocrystals (Lipid-NCs) were about 100 nm, homogeneous, stable and showed improved drug release compared to pure PTX. The nanocrystals were…
Read More...
Read More...
Autoclaving behavior of trimyristin nanoemulsions stabilized with different poloxamers
Abstract
Lipid nanoemulsions are being investigated as carrier systems for the parenteral administration of poorly soluble drugs. Defined particle sizes, narrow particle size distributions, and sterility are prerequisites for the safe administration of such formulations to patients. In the current…
Read More...
Read More...
Hansen Solubility Parameter Approach in the Screening of Lipid Excipients for the Development of…
Abstract
Background
The complex physicochemical properties of the lipids have considerable impact on the solubility and stability of the Lipid Based Nanocarriers (LBN). The major challenge in the successful development of LBN lies on the selection of suitable lipid and its ability to achieve…
Read More...
Read More...