Stabilizer

Abstract Resins are complex mixtures of natural constituents containing non-volatile and volatile terpenes, in combination with gums and polyphenols, used since ancient times for their medicinal properties. Current research has evidenced their therapeutic value with a plethora of activities. The…
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Many challenges – one solution: Fumed silica as well as precipitated silica and silicates from Evonik are some of the most important and highly utilized pharmaceutical excipients. Whether you manufacture medicines for solid, semi-solid or liquid dosing, we support you at every stage of product…
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Sodium L-glutamate, better known as Monosodium glutamate (MSG) by Dr. Paul Lohmann® , has emerged as a crucial component in bioproduction processes, particularly in the cultivation of certain microorganisms, significantly enhancing biopharmaceutical processes. Applications in growth media…
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Abstract Rheumatoid arthritis damages the synovial membrane, and diflunisal, a nonsteroidal anti-inflammatory drug (NSAID) with poor solubility, faces delivery challenges. Nanosponges enhance diflunisals solubility improving its bioavailability; in addition it improved its stability and controls…
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Abstract Poor solubility of many drugs, with ensuing low bioavailability, is a big challenge in pharmaceutical development. Nanosuspensions have emerged as a platform approach for long-acting injectables and solid dosages that enhance drug bioavailability. Despite improvements in nanosuspension…
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Abstract Lidocaine (LID), frequently used in dermal applications, is a nonpolar local anesthetic agent that is practically insoluble in water. The main aim of this study is to develop the nanosuspension formulation of LID using the design of experiments (DoE). The improved solubility and…
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Abstract Curcumin (CUR), a polyphenolic pigment of turmeric, -possess biological and medicinal properties. Regardless of having a wide range of therapeutic applications, CUR’s poor bioavailability, owing to its meagre solubility and stability, limits its application from being used as a…
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The patent WO2019123269A1, titled “Packaged modified release gamma-hydroxybutyrate formulations having improved stability“ presents innovative formulations and packaging methods designed to enhance the dissolution and chemical stability of gamma-hydroxybutyrate (GHB), a treatment for narcolepsy.…
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Abstract Previously, a nasal powder formulation of the influenza vaccine was proposed to ensure its stability over fifteen months at room temperature and to have sufficient moisture-resistant characteristics to enable handling without special humidity control. In this study, a carrier-based…
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Abstract Diffuse intrinsic pontine glioma (DIPG) poses a significant treatment challenge in pediatric patients due to its aggressive nature and difficulty in crossing the blood–brain barrier with effective therapies. ONC201 (dordaviprone) shows promises in inducing apoptosis in cancer cells but…
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