Stabilizer

Abstract Aim Proteolysis targeting chimeras (PROTACs) exhibit a unique and promising pharmacology. However, this comes with molecular properties exceeding the ‘drug-like’ rule of five chemical space, which often limits gastrointestinal absorption. This in vivo study aimed to investigate the…
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Pharma Excipients proudly present the new webinar with Roquette and Catalent: Optimizing Pharmaceutical Formulations: Strategies for Improving Stability and Minimizing Impurities About the Webinar: Join Amit Chivate, Ph.D., MBA, Senior Area Marketing Manager for Greater…
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Abstract Novel branched copolymer surfactants (BCS) allow the formation of oil-in-water emulsions that exhibit a temperature-induced liquid-to-gel transition. If the temperature of this transition is between room and body temperature (ca 25 and 37 °C, respectively), then the emulsions form a gel in…
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Abstract Purpose Posaconazole (POS) is widely used as an antifungal agent effective against Candida infections. Because of its very low water and high fat solubility, it falls under the Biopharmaceutics Classification System (BCS) Class II. It showed considerable differences in absorption rates…
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Abstract Cyclodextrins (CDs) play a crucial role in pharmaceutical formulations due to their unique ability to form inclusion complexes with a wide range of lipophilic drugs. Ternary complexes comprising CD, water-soluble polymer, and drug molecule have emerged as promising multicomponent to the…
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Roquette presents a new product: KLEPTOSE® F 7% - EXP β-cyclodextrin for oral dosage forms contains less than 7% of water. It is well suited for dry processing techniques, such as direct compression, where its low water content benefits moisture-sensitive APIs and formulations (e.g., ODTs,…
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Abstract Ternary co-amorphous systems, comprising a drug, a low molecular weight co-former, and a polymer, are a promising approach to address the solubility and stability challenges of poorly water-soluble drugs. However, it is unclear how the addition of a third component influences the stability…
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Abstract The current study includes the design of soluplus stabilized, lipid-coated, and fucoidan-oleylamine conjugate modified paclitaxel nanocrystals. The nanocrystals (Lipid-NCs) were about 100 nm, homogeneous, stable and showed improved drug release compared to pure PTX. The nanocrystals were…
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Abstract Lipid nanoemulsions are being investigated as carrier systems for the parenteral administration of poorly soluble drugs. Defined particle sizes, narrow particle size distributions, and sterility are prerequisites for the safe administration of such formulations to patients. In the current…
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Abstract Background The complex physicochemical properties of the lipids have considerable impact on the solubility and stability of the Lipid Based Nanocarriers (LBN). The major challenge in the successful development of LBN lies on the selection of suitable lipid and its ability to achieve…
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