Solubility improvement of curcumin by crystallization inhibition from polymeric surfactants in amorphous solid dispersions

27. March 2023

To improve the solubility and maintain the amorphous state of BCS Ⅳ drug by preparing surfactant solid dispersions, solid dispersions...

Solid-in-oil nanodispersion as a novel topical transdermal delivery to enhance stability and skin permeation and retention of hydrophilic drugs l-ascorbic acid

15. March 2023

l-ascorbic acid （Vitamin C, VC）is the most abundant antioxidant in human skin. But its poor penetration into the skin and...

Oligonucleotide Formulations Prepared by High-Speed Electrospinning: Maximizing Loading and Exploring Downstream Processability

14. March 2023

The aim of this study was to develop antisense oligonucleotide tablet formulations using high-speed electrospinning. Hydroxypropyl-beta-cyclodextrin (HPβCD) was used as...

Development and Stability of a New Formulation of Pentobarbital Suppositories for Paediatric Procedural Sedation

7. March 2023

Pentobarbital is a drug of choice to limit motion in children during paediatric procedural sedations (PPSs). However, despite the rectal...

Overcoming Challenges in Ophthalmic Formulations through Polymer Selection

7. March 2023

Ophthalmic drugs are delivered to the eye to treat chronic diseases such as dry eye and acute conditions such as...

Development of Mefenamic Acid-Soluplus® amorphous dispersions via hot melt extrusion and in silico prediction of oral absorption

3. March 2023

The objective of this study was to increase the solubility of Mefenamic Acid (MA), a BCS class II drug by...

Amorphous Solid Dispersions Layered onto Pellets – An Alternative to Spray Drying?

2. March 2023

Spray drying is one of the most frequently used solvent-based processes for manufacturing amorphous solid dispersions (ASDs). However, the resulting...

Trehalose in Biomedical Cryopreservation–Properties, Mechanisms, Delivery Methods, Applications, Benefits, and Problems

22. February 2023

Cells and tissues are the foundation of translational medicine. At present, one of the main technological obstacles is their preservation...

Fabrication of Celecoxib PVP Microparticles Stabilized by Gelucire 48/16 via Electrospraying for Enhanced Anti-Inflammatory Action

15. February 2023

Electrospraying (ES) technology is considered an efficient micro/nanoparticle fabrication technique with controlled dimensions and diverse morphology. Gelurice® 48/16 (GLR) has been...

Engineered Lipid Excellence For Topical Application_IOI Oleo_Title

Engineered Lipid Excellence For Topical Applications – IOI Oleo

15. February 2023

Tried & Trusted, Quality & Innovation With our nature-based excipients you can develop modern pharmaceutical topical formulations that combine functionality,...

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