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Ashland
Controlled release of amitriptyline via the transdermal route using SmartReservoirs and…
Abstract
SmartReservoirs (SRs) are novel drug reservoirs made from a cellulose-based matrix for hydrogel-forming microneedles (HF-MNs). SRs can incorporate drug molecules within a cellulose-based matrix in amorphous form. This significantly improves the solubility of poorly soluble drugs, which…
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Assessment of leachables and extractables in “super-swelling” hydrogel-forming microarray patches
Abstract
Hydrogel-forming microarray patches (MAPs) offer a minimally invasive platform for transdermal drug delivery, enabling systemic absorption of active pharmaceutical ingredients. Unlike dissolving MAPs, which deposit their entire polymer matrix into the skin, hydrogel-forming MAPs remain…
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Hydroxypropyl-β-Cyclodextrin-Enhanced Azelaic Acid Hydrogel for Acne Treatment: Evaluation of…
Abstract
Purpose
Azelaic acid (AZE) is a widely used agent in acne treatment, but its poor water solubility limits its therapeutic potential. In this study, the effectiveness of azelaic acid (AZE)—a compound with limited therapeutic efficacy due to its poor water solubility—was investigated in…
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Biosurfactant Stabilized Nanosuspension of KRAS inhibitor – Sotorasib (AMG-510): Systematic…
Abstract
This research study aimed to develop and evaluate a novel freeze-dried nanocrystals formulation of sotorasib (AMG-510) using Quality by Design (QbD) approach to enhance solubility, dissolution, and oral bioavailability. A QbD framework use for identification, optimization and validation of…
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Predicting the tabletability of binary powder mixtures from that of individual components
Abstract
Predicting the tabletability, i.e., the relationship between tensile strength and compaction pressure, of powder mixtures based on that of pure materials would streamline tablet formulation development, saving both time and materials. This would be a significant step toward achieving…
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Enhanced stability of levodopa and benserazide fixed-dose combination tablets through optimized…
Abstract
Parkinson's disease is a debilitating neurodegenerative disorder that is primarily characterized by dopamine deficiency, which significantly impairs motor function and quality of life. Levodopa remains the gold standard treatment due to its efficacy in replenishing dopamine levels.…
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Development of Gastro-Retentive Combination Formulation of Montelukast Sodium and Bepotastine…
Abstract
Aim: The study aimed to develop a once-daily sustained-release gastroretentive combination formulation of bepotastine besilate and montelukast sodium using multilayer tablet technology and gastro-retentive systems for the treatment of allergic rhinitis and asthma.
Background:…
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Ethyl-Cellulose Nanosponges for Topical Delivery of Simvastatin with Preferential Skin Retention for…
Abstract
Novel topical nanosponges were implemented to improve the skin availability of simvastatin (SV) for treating full-thickness wounds while controlling the scarring process. SV exhibits great potential in treating various skin diseases owing to its antibacterial, antioxidant,…
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A Novel Semi-Automated Pipeline for Optimizing 3D-Printed Drug Formulations
Abstract
3D printing offers a promising approach to creating personalized medicines. However, costly, expertise-dependent trial-and-error methods hinder efficient drug formulation, posing challenges for tailoring treatments to individual patients. To address this, a novel pipeline is developed for…
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Electrospun Nanofiber-Scaffold-Loaded Levocetirizine Dihydrochloride Cerosomes for Combined…
Abstract
Objectives: In this study, we aimed to incorporate levocetirizine dihydrochloride (LVC) into electrospun nanovesicle-in-nanofiber (NF) scaffolds for combined management of atopic dermatitis and methicillin-resistant Staphylococcus Aureus skin infection, to sustain LVC release for…
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