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Dissolving microarray patches for transdermal delivery of risperidone for schizophrenia management
Schizophrenia is a psychiatric disorder that results from abnormal levels of neurotransmitters in the brain. Risperidone (RIS) is a common drug prescribed for the treatment of schizophrenia. RIS is a hydrophobic drug that is typically administered orally or intramuscularly. Transdermal drug delivery…
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Quality by design approach for fabrication of extended-release buccal films for xerostomia employing…
The study endeavors the fabrication of extended-release adipic acid (APA) buccal films employing a quality by design (QbD) approach. The films intended for the treatment of xerostomia were developed utilizing hot-melt extrusion technology. The patient-centered quality target product profile was…
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Transformation of ABT-199 Nanocrystal Suspensions into a Redispersible Drug Product – Impact…
The present study compared vacuum drum drying (VDD) and conventional spray drying (SD) for solidifying crystalline ABT-199 nanosuspensions into redispersible oral drug products. The aim was to optimize formulation compositions and process conditions to maintain nanoparticle size after tablet…
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Enhanced Bioavailability of Valsartan through Mucoadhesive Pellets Fabricated via Fluidized Bed…
ABSTRACT
Background
Novel delivery strategies are being explored since low bioavailability presents a challenge for medications like valsartan. Mucoadhesive drug delivery systems present a viable alternative by enhancing drug absorption and retention.
Aim
This study aimed to develop…
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Formulation and evaluation of ivermectin-loaded dissolving microarray patches for rosacea disease
Abstract
Purpose
This investigation aims to develop and characterise dissolving microarray patches (MAPs) loaded with ivermectin (IVM) for rosacea therapy.
Methods
Tween® 80 and Soluplus® were evaluated to enhance the water solubility of IVM powder. Three dissolving MAPs were fabricated using…
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Comprehensive Review of Modern Techniques of Granulation in Pharmaceutical Solid Dosage Forms
ABSTRACT
This comprehensive review explores modern granulation techniques in pharmaceutical dosage forms along with conventional methods, focusing on dry granulation and wet granulation. Dry granulation techniques, including slugging, roller compaction, and pneumatic dry granulation, are…
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Evaluating Solubility, Stability, and Inclusion Complexation of Oxyresveratrol with Various…
Oxyresveratrol (OXY), a natural stilbenoid in mulberry fruits, is known for its diverse pharmacological properties. However, its clinical use is hindered by low water solubility and limited bioavailability. In the present study, the inclusion complexes of OXY with β-cyclodextrin (βCD) and its three…
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Mannitol-coated hydroxypropyl methylcellulose as an alternative directly compressible controlled…
One of the most common forms of controlled release technology for oral drug delivery comprises an active ingredient dispersed in a hydrophilic matrix forming polymer such as hydroxypropyl methylcellulose (HPMC), which is tableted via direct compression. However, HPMC may pose problems in direct…
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Calcipotriol Nanosuspension-Loaded Trilayer Dissolving Microneedle Patches for the Treatment of…
Psoriasis, affecting 2–3% of the global population, is a chronic inflammatory skin condition without a definitive cure. Current treatments focus on managing symptoms. Recognizing the need for innovative drug delivery methods to enhance patient adherence, this study explores a new approach using…
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Novel nano-in-micro fabrication technique of diclofenac nanoparticles loaded microneedle patches for…
Abstract
Diclofenac, a nonsteroidal anti-inflammatory drug, is commonly prescribed for managing osteoarthritis, rheumatoid arthritis, and post-surgical pain. However, oral administration of diclofenac often leads to adverse effects. This study introduces an innovative nano-in-micro approach to…
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