BASF Poster

This poster was presented at the PBP World Meeting 2024 in Vienna: BACKGROUND & INTRODUCTION Topical film-forming solutions (FFSs) represent an innovative form of sustained release dermatological dosage forms. They can be applied to the skin as solutions, gels or sprays. After evaporation of…
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Kollicoat® Smartseal 30 D and Kollicoat® Smartseal 100 P can help formulators tackle challenges when handling bitter active ingredients. It offers superior protection from unpleasant drug taste for minitablets, pellets, particles, and granules used in orally disintegrating dosage forms, improving…
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INTRODUCTION Plasticiser play a decisive role in the application of functional films, especially, if an aqueous dispersion containing a water insoluble polymer is used. For the water insoluble sustained release film forming polymer PVAc, both elongation at break and minimum film forming temperature…
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Introduction: Drug stability and shelf life are main targets of current pharmaceutical development as many active ingredients are highly moisture sensitive. Instead of using impermeable and expensive packaging materials it appears advisable to test moisture protective instant release film coatings.…
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Delivering active ingredients via orally dispersible tablets (ODTs) is a recent trend in the pharmaceutical industry. Due to the easy and fast application, patient’s compliance is high for this kind of dosage form. To ensure a fast drug release, ODTs are typically not coated. Nevertheless, a…
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Novel excipients can play a major role in innovation processes, but physicochemical properties, performance and safety must be adequately demonstrated. Characterization requirements for novel excipients are discussed and illustrated with two examples, polyethyleneglycol-polyvinyl caprolactam…
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The purpose of this study was to evaluate the performance of the surfactants Polyoxyl 15 Hydroxystearate (Kolliphor® HS 15) and Polyoxyl-35-castor oil (Kolliphor® ELP) in stabilizing proteins formulations. Surfactants are an essential component of biologics formulations, as they stabilize protein…
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Taste-masking has proven to be a useful technique to improve patient compliance of oral dosages having bitter actives, especially for pediatric and geriatric products. Kollicoat® Smartseal 100P, a spray dried powder of methyl methacrylate-diethylaminoethyl methacrylate copolymer is an excellent…
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Various active pharmaceutical ingredients (APIs) are either aggres­sive to the stomach’s mucosa or vulnerable to the acidic nature of the gastric juice. Solid oral dosage forms carrying one of these APIs thence require gastric resistant functionality. Poly(methacrylic acid-co-ethyl acrylate) based…
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Developing a gastric resistant coating formulation can be quite demanding. There are a lot of interactions between polymer and active ingredient or non-functional excipients which have to be heeded. Even if all incompatibilities could be eliminated, the disintegration characteristics of the core…
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