Strategies and Mechanism in Reversing Intestinal Drug Efflux in Oral Drug Delivery

1. June 2022

Efflux transporters distributed at the apical side of human intestinal epithelial cells actively transport drugs from the enterocytes to the...

Determination of Solubility of Solid Lipids and Surfactants

Development of Dapagliflozin Solid Lipid Nanoparticles as a Novel Carrier for Oral Delivery: Statistical Design, Optimization, In-Vitro and In-Vivo Characterization, and Evaluation

30. May 2022

Controlling hyperglycemia and avoiding glucose reabsorption are significant goals in type 2 diabetes treatments. Among the numerous modes of medication...

Nanoemulgel: For Promising Topical and Systemic Delivery

27. May 2022

Nanoemulgel delivery system is a fusion of two different delivery systems, wherein the physical state of drug containing nanoemulsion is...

Systematic Development of Solid Lipid Nanoparticles of Abiraterone Acetate with Improved Oral Bioavailability and Anticancer Activity for Prostate Carcinoma Treatment

26. May 2022

In the present work, an attempt was undertaken to improve the oral bioavailability and anticancer activity of abiraterone acetate. Solid...

Dual Drug Loaded Lipid Nanocarrier Formulations for Topical Ocular Applications

24. May 2022

Introduction: Untreated ocular infections can damage the unique fine structures of the eye with possible visual impairments and blindness. Ciprofloxacin...

Digestion of lipid excipients and lipid-based nanocarriers by pancreatic lipase and pancreatin

22. May 2022

The digestion behaviour of lipid-based nanocarriers (LNC) has a great impact on their oral drug delivery properties. In this study,...

Croda announces the new Pharma business

18. May 2022

Croda has announced that its Health Care division will now become Croda Pharma, bringing its core speciality excipient portfolio together...

Medical officer prepares a dose of Moderna COVID-19 vaccine during the third dose inoculation program for health workers in Mangusada Hospital, Bali, Indonesia on August 4 2021. Indonesian health workers receives the third dose COVID-19 vaccine using mRNA based vaccine from Moderna in order to boost their body's immune system and protect them from the new variant of coronavirus which has surged over the past few weeks in Indonesia. (Photo by Johanes Christo/NurPhoto via Getty Images)

Better fat bubbles could power a new generation of mRNA vaccines

15. May 2022

New lipid delivery systems aim to improve potency and reduce side effects As any dietician will tell you, some fats...

An imidazole modified lipid confers enhanced mRNA-LNP stability and strong immunization properties in mice and non-Human primates

13. May 2022

The mRNA vaccine technology has promising applications to fight infectious diseases as demonstrated by the licensing of two mRNA-based vaccines,...

Exploring bulk volume, particle size and particle motion definitions to increase the predictive ability of in vitro dissolution simulations

11. May 2022

The definition of the local dissolution environment is central to accurate particle dissolution simulation, and is determined by the apparatus...

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