Nanoemulgel: For Promising Topical and Systemic Delivery
Nanoemulgel delivery system is a fusion of two different delivery systems, wherein the physical state of drug containing nanoemulsion is changed by adding it to the gel matrix, thus enabling more lipophilic drugs to be used in treatment therapies. It solves the major issues such as limiting use of lipophilic drugs, poor oral bioavailability, and unpredictable pharmacokinetic and absorption variations. Simultaneously, its nongreasy nature and easily spreading ability support the patient compliance. Nanoemulgel can be widely used in the treatment of acne, pimple, psoriasis, fungal infection, and inflammation cause by osteoarthritis and rheumatoid arthritis. The delivery of drug via ocular, vaginal, dental, and nose to brain routes for the treatment of diverse local and systemic ailments for instance alopecia, periodontitis, and Parkinson’s are possible. In the cosmetic industries, UV absorber nanoemulgel protected skin from sunburn.
Figure 2: Potent formulation component of nanoemulgel
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Excipients named in the paper besides others: Labrafac, Capryol 90, Capryol PGMC, Maisine 35, Capmul MCM, Labrafil, Tween 20, Polysorbate 80, Kolliphor Rh40, PEG 400, Cremophore Rh40, Transcutol P, Carbomer 934, Carbopol 940, Poloxamer, HPMC 55
Sultana, N., Akhtar, J., Badruddeen, B., Khan, M. I. , Ahmad, U., Arif, M., Ahmad, M., & Upadhyay, T. (2022). Nanoemulgel: For Promising Topical and Systemic Delivery. In J. Akhtar, Badruddeen, M. Ahmad, & M. I. Khan (Eds.), Drug Development Life Cycle [Working Title]. IntechOpen. https://doi.org/10.5772/intechopen.103878