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Cyclolab
Alternative Excipients for Protein Stabilization in Protein Therapeutics: Overcoming the Limitations…
Given their safety and efficiency in protecting protein integrity, polysorbates (PSs) have been the most widely used excipients for the stabilization of protein therapeutics for years. In recent decades, however, there have been numerous reports about visible or sub-visible particles in…
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Inclusion complexation and liposomal encapsulation of an isoniazid hydrazone derivative in…
Tuberculosis, a predominantly pulmonary pathology, is currently the deadliest infection worldwide. Its treatment is based on combination therapy involving selected antimicrobials including Isoniazid. However, physicochemical properties of isoniazid negatively affect the clinical performance of…
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Cyclodextrin-enabled nepafenac eye drops with improved absorption open a new therapeutic window
Nepafenac is a highly effective NSAID used for treating postoperative ocular inflammation and pain after cataract surgery and its advantage over conventional topical NSAIDs has been proved many times. However, Nevanac® is a suspension eye drop, which clearly lacks patient compliance causing…
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The Role of Cyclodextrins in COVID-19 Therapy—A Literature Review
Coronavirus disease-19 (COVID-19) emerged in December 2019 and quickly spread, giving rise to a pandemic crisis. Therefore, it triggered tireless efforts to identify the mechanisms of the disease, how to prevent and treat it, and to limit and hamper its global dissemination. Considering the above,…
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A Current Overview of Cyclodextrin-Based Nanocarriers for Enhanced Antifungal Delivery
Fungal infections are an extremely serious health problem, particularly in patients with compromised immune systems. Most antifungal agents have low aqueous solubility, which may hamper their bioavailability. Their complexation with cyclodextrins (CDs) could increase the solubility of antifungals,…
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Development and Characterization of Cyclodextrin-Based Nanogels as a New Ibuprofen Cutaneous…
Nanogels combine the properties of hydrogels and nanocarrier systems, resulting in very effective drug delivery systems, including for cutaneous applications. Cyclodextrins (CDs) have been utilised to enhance the nanogels’ loading ability towards poorly soluble drugs and promote/sustain drug…
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Alternative Methotrexate Oral Formulation: Enhanced Aqueous Solubility, Bioavailability,…
The poor aqueous solubility and/or permeability and thereby limited bioavailability largely restricts the pharmaco-therapeutic implications of potent anticancer drugs such as methotrexate (MTX). Furthermore, MTX’s inherently unstable nature makes it difficult to develop a viable oral formulation. In…
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Your visit at CPHI worldwide 2022 in Frankfurt
CPHI worldwide opens its doors again. This year in Frankfurt at the Messe Frankfurt. In two weeks, from 1st to 3rd November, you can finally have a face-to-face chat with visitors and exhibitors again. As usual, InnoPack, P-MEC, FDF, ICSE and BioProduction will be held together with CPHI.
The…
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An Updated Overview of Cyclodextrin-Based Drug Delivery Systems for Cancer Therapy
Encompassing a group of complex and heterogeneous diseases, cancer continues to be a challenge for patients and healthcare systems worldwide. Thus, it is of vital importance to develop advanced treatment strategies that could reduce the trends of cancer-associated morbidity and mortality rates.…
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Eudragit® L100/Polyvinyl Alcohol Nanoparticles Impregnated Mucoadhesive Films as Ocular Inserts for…
The fast elimination of drugs from the cornea is one of many challenges associated with the topical administration of conventional dosage forms. The present manuscript aimed to prepare modified-release inserts containing erythromycin (ERY) to enhance drug delivery and address the aforementioned…
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