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Comparison of the liquisolid technique and co-milling for loading of a poorly soluble drug in…
Abstract
Drug loading into mesoporous carriers may help to improve the dissolution of poorly aqueous-soluble drugs. However, both preparation method and carrier properties influence loading efficiency and drug release. Accordingly, this study aimed to compare two preparation methods: formulation…
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Controlled release mechanism of thymol loaded into mesoporous silica nanoparticles for active…
In order to overcome the poor water solubility and instability of thymol to enhance its bioavailability, mesoporous silica nanoparticles (MSNPs: SBA-15, SBA-16 and MCM-41) with different pore structures were developed using solution-gel method to carry and release thymol. The N2 …
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Evaluation the Injectability of Injectable Microparticle Delivery Systems on the Basis of Injection…
Background
Subcutaneous injection of biopharmaceutical agents or microparticles is challenging due to issues with low injection efficiency and high residual amounts.
Objective
This study aimed to determine the important factors affecting the injectability of microparticle delivery…
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Development of Doxazosin mesylate liquisolid system for improved manufacturing processability and…
In the present research, an attempt was made to optimize the blends of different carriers Neusilin US2, Avicel PH101, and Fujicalin SG by individually blending with each of coating materials Aerosil 200 and Syloid 244 FP that were proposed to contribute to a modified drug dissolution rates of…
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Study of the feeding performance of mesoporous silica in a loss-in-weight feeder
Accurate and reliable continuous feeding is essential for the continuous manufacturing of solid-dose pharmaceuticals to ensure the reproducible composition of the final product. Consistent feeding of cohesive powders is challenging and requires an understanding of the interplay between material…
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Evaluating the effect of glidants on tablet sticking propensity of ketoprofen using powder rheology
Punch sticking has been a leading drawback that has challenged successful tablet manufacturing since its initial conception. Due to the capricious nature of the complication, this can arise during any phase of the development process. Even now, identifying such a problem is a prerequisite during the…
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Production challenges of tablets containing lipid excipients: Case study using cannabidiol as drug…
The aims of this study were, firstly, to select an optimal lipid solid dispersion of cannabidiol among different lipid excipients (Gelucire® 50/13, 48/16, 44/14 and Labrasol®) and inorganic carriers (colloidal silica, Syloid® XDP and Neusilin® US2) through a screening plan. The enhancement of…
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Solubility enhancement study of lumefantrine by formulation of liquisolid compact using mesoporous…
Lumefantrine, exhibits poor bioavailability due to its very low solubility. A liquisolid compact of lumefantrine was prepared with mesoporous silica as a novel coating material. Lactose anhydrous and syloid 244FP were selected as carrier and coating materials respectively. Varying the carrier to…
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High-Shear Wet Granulation of SMEDDS Based on Mesoporous Carriers for Improved Carvedilol Solubility
Mesoporous carriers are a convenient choice for the solidification of self-microemulsifying drug delivery systems (SMEDDS) designed to improve the solubility of poorly water-soluble drugs. They are known for high liquid load capacity and the ability to maintain characteristics of dry, free-flowing…
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Multivariate Data Analysis and Central Composite Design-Oriented Optimization of Solid Carriers for…
The study was initiated with two major purposes: investigating the role of isomalt (GIQ9) as a pharmaceutical carrier for solid self-nanoemulsifying drug delivery systems (S-SNEDDSs) and improving the oral bioavailability of lipophilic curcumin (CUN). GIQ9 has never been explored for solidification…
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