Merck

Abstract Pediatric maintenance therapy for acute lymphoblastic leukemia requires prolonged daily administration of 6-mercaptopurine (6-MP), a drug characterized by a...

Abstract Background/Objectives: Matrix pellet formulations enable homogeneous incorporation of the active ingredient and advanced control of release depending on the...

Abstract Purpose: To formulate enteric-coated osmotic tablets for colon-targeted delivery of hydrocortisone. Methods: Nine core tablet batches were prepared with...

AI in pharmaceutical drug product design is, in 2026, a decision-support technology, not autonomous formulation. The most mature tools combine...

Abstract Poloxamer-based hydrogels, composed of thermoreversible triblock copolymers, are promising drug delivery systems due to their ability to transition from...

Abstract Spray dried dispersion (SDD) is increasingly used in solid dose formulations for poorly soluble active pharmaceutical ingredients (APIs). Dissolution...

Abstract Background/Objectives. Warfarin possesses a bitter taste and requires a personalized dose in the range of 4.5 to 77 mg per...

Abstract Preservatives are critical for preventing microbial contamination in multi-dose biologics, yet their compatibility with proteins poses a major challenge....

Abstract Background/Objectives: Rebamipide is a gastroprotective agent with poor aqueous solubility and rapid gastrointestinal clearance, leading to reduced therapeutic efficiency. This...

Abstract The layering of active pharmaceutical ingredient (API) suspension on inert carriers through fluid bed granulation has been tackled in...