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Merck
Transformation of Ritonavir Nanocrystal Suspensions into a Redispersible Drug Product via Vacuum…
The present study explored vacuum drum drying (VDD) as potential drying technique for the solidification of crystalline ritonavir nanosuspensions prepared by wet-ball milling. In detail, the impact of drying protectants (mannitol, lactose, trehalose) added to the ritonavir nanosuspension was…
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Semi-solid extrusion 3D printing of tailored ChewTs for veterinary use – A focus on…
Currently, there are a few or none marketed gabapentin veterinary products, leading to treatment with compounded dosage forms or off-label use of human-marketed products. With the said approaches, there are significant risks of preparation errors, rendering these practices suboptimal. A new…
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Proof-of-Concept for Adjusted Surface Energies and Modified Fines as a Novel Concept in Particle…
Currently marketed dry powder inhaler (DPI) medicine lacks drug delivery performance due to insufficient powder dispersion. In carrier-based blends, incomplete drug detachment is typically attributed to excessive adhesion forces between carrier and drug particles. Adding force control agents (FCA)…
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Fast In Vitro Release and In Vivo Absorption of an Anti-Schizophrenic Drug Paliperidone from Its…
The purpose of this study was to develop a drug delivery system for paliperidone (PPD) in order to provide a more effective therapeutic strategy for patients with acute schizophrenia. PPD-loaded Soluplus®/TPGS mixed micelles (PPD-S/T-MM) were prepared using the thin-film hydration method. The…
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Predictive modelling of powder compaction for binary mixtures using the finite element method
Despite the widespread use of solid-form drug delivery within the pharmaceutical industry, tablets remain challenging to formulate because their properties depend strongly on the powder composition and details of the compaction process. Powder compaction simulations, using the finite element method…
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Formulation, Preparation, Characterization, and Evaluation of Dicarboxylic Ionic Liquid Donepezil…
Abstract
Donepezil (DPZ) is generally administered orally to treat Alzheimer’s disease (AD). However, oral administration can cause gastrointestinal side effects. Therefore, to enhance compliance, a new way to deliver DPZ from transdermal patch was developed. Ionic bonds were created by…
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Advantages of Mannitol in Pharmaceutical Granulation Processes – A Comparison of Different…
Granulation is employed during production of oral dosage forms to convert small particles of powder ingredients and the active pharmaceutical ingredient (API) into large, free-flowing, dust-free, compressible granules, ensuring uniform distribution of ingredients throughout the resulting mixture.…
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Optimization of the Conditions of Solid Lipid Nanoparticles (SLN) Synthesis
Solid lipid nanoparticles (SLNs) have been synthesized as potential drug delivery systems. They are classified as solid lipid nanocarriers that can successfully carry both hydrophilic and hydrophobic drugs. SLNs are based on a biocompatible lipid matrix that is enzymatically degraded into natural…
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Modernising Orodispersible Film Characterisation to Improve Palatability and Acceptability Using a…
Orodispersible films (ODFs) have been widely used in paediatric, geriatric and dysphagic patients due to ease of administration and precise and flexible dose adjustments. ODF fabrication has seen significant advancements with the move towards more technologically advanced production methods. The…
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Enhancement of Tablet Coating using an Innovative Functional Excipient
During formulation of solid dosage forms, film coating is used to improve the appearance and stability of tablets, make them easier to swallow, mask the taste, modify or sustain release, protect the drug from the harsh gastric environment, protect from moisture and/or oxidation and, as a result, to…
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