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Merck
3D Printing in Oral Drug Delivery: Technologies, Clinical Applications and Future Perspectives in…
Abstract
The recent advancement of 3D-printed drugs is an emerging technology that has the potential for effective and safe oral delivery of personalized treatment regimens to patients, replacing the current “one size fits all” philosophy. The objective of this literature review is to highlight the…
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Effects of alginate inclusion on quality attributes and storage stability of gelatin oral pellets…
Abstract
Ionic liquid (IL) salts of active pharmaceutical ingredients (API) represent promising formulations for poorly-soluble APIs as they eliminate polymorphism commonly associated with conventional API salts. Being highly viscous liquid, oral dosage formulation of API-ILs is challenging,…
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Preparation and Characterization of Diclofenac Sodium-Purolite A430MR Complexes for Taste Masking
Abstract
The taste of a drug impacts the compliance of patients for oral administration. In this study, the bitter taste of diclofenac sodium (DS) was masked with purolite A430MR through ion exchange. The DS-A430MR complexes (DACs) were prepared at a 1:1 (w/w) drug to resin through a simple aqueous…
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Experimental investigation of compression and wetting behavior of liquisolid systems with different…
Abstract
Liquisolid systems prepared in a fluidised bed processor were investigated to evaluate the suitability of four different porous excipients (Fujicalin®, Neusilin® US2, Syloid® XDP 3050 and Syloid® XDP 3150) as carriers in high liquid content formulations. PEG 400 was used as liquid phase…
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Feasibility of Hot Melt Extrusion in Converting Water-Based Nanosuspensions into Solid Dosage Forms
Abstract
Aim: In addition to numerous benefits provided by nanosuspensions (NSs) (e.g., enhanced saturation solubility, increased area for interaction with fluids), they suffer from major stability, handling and compliance issues. To overcome these challenges, we evaluated the feasibility of hot…
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Novel ethosomal gel formulation for enhanced transdermal delivery of curcumin and cyclosporine: a…
Abstract
Vesicular systems have demonstrated efficacy in the management of Rheumatoid Arthritis (RA). This study explores the synergistic effect of edge-activated ethosomal gel to enhance the transdermal delivery of Curcumin (CUR) and Cyclosporine (CYC). Ethosomal vesicles prepared via the ethanol…
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Impact of antioxidant addition on drug dissolution: Implications for NDSRI mitigation biowaivers
Abstract
Nitrosamine impurities have garnered recent attention due to their presence in pharmaceuticals and their mutagenic risks. Recent studies have emphasized controlling impurities and suggest ways to mitigate the further formation of nitrosamines by the addition of antioxidants to tablets and…
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Biosurfactant Stabilized Nanosuspension of KRAS inhibitor – Sotorasib (AMG-510): Systematic…
Abstract
This research study aimed to develop and evaluate a novel freeze-dried nanocrystals formulation of sotorasib (AMG-510) using Quality by Design (QbD) approach to enhance solubility, dissolution, and oral bioavailability. A QbD framework use for identification, optimization and validation of…
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3D-Printed cannabidiol stent for local treatment of urinary tract infections
Abstract
Urinary tract infections (UTIs) are highly prevalent among women and those assigned female at birth, and frequently necessitate the administration of systemic antibiotics, which contributes to the antibiotic resistance crisis due to overuse and suboptimal patient adherence. This study…
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Combining high throughput ASD screening with the rDCS to streamline development of poorly soluble…
Abstract
Poor aqueous solubility and slow dissolution rate of active pharmaceutical ingredients (APIs) are often encountered challenges during oral drug development, leading to variable and insufficient bioavailability. To overcome these challenges, a so-called “enabling” formulation strategy is…
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