Merck

Abstract The flavonoid hesperidin is a crucial, biologically active substance of great interest because of its polypharmacological properties and high safety profile. However, its widespread use of this bioflavonoid in remedies for the treatment and prevention of various diseases is limited by its…
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Abstract Powder flow characteristics are crucial for efficient processing and manufacturing in the pharmaceutical industry. The occurrence of tribo-charging, a surface phenomenon where particles acquire an electrical charge due to frictional contacts with other particles or surfaces, poses risks…
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Abstract Dual-pattern drug release systems are a new type of drug delivery system designed to achieve both immediate and sustained drug release. This study developed a dual-pattern system by combining orally disintegrating films (ODFs) with mucoadhesive nanoparticles (NPs). The NPs were made from…
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Abstract A tunable modular design (TMD) as a new approach was proposed to tailor the dose and drug release profile of poorly water-soluble drugs from hydroxypropyl methylcellulose (HPMC)-based solid foams by combining two manufacturing principles: (1) freeze-drying aqueous HPMC-based gels to…
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Abstract Inkjet printing is emerging as a valuable tool for personalised medicine, offering precision and flexibility in pharmaceutical development. Efforts have been made to modify commercial desktop printers; however, the growing demand for decentralized and on-demand pharmaceutical production…
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Abstract Solid forms transformations and new crystal structures of an active pharmaceutical ingredient (API) can occur due to various manufacturing process conditions, especially if the drug substance is formulated as a hydrate. The conversion between hydrate and anhydrate forms caused by changes…
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Abstract Cutaneous fungal infections pose a significant health challenge, particularly in deeper skin layers where topical treatments are ineffective. Amphotericin B (AmB) is the gold standard for treating fungal infections, but its poor solubility limits its transdermal delivery. In this work, AmB…
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Abstract Topical skin products aim to address aesthetic, protective, and/or therapeutic needs through interaction with the human epidermal system. Traditionally, formulation development relies on empirical knowledge and trial-and-error experiments. In this paper, we introduced the Bayesian…
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Abstract For monoclonal antibody drug products as for other biologics, while the innovator drug products first becomes commercially available, they are often followed by one or more biosimilar products. These biosimilars often differ from the innovator product, as well as from each other, in…
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Abstract Probiotics, which play a crucial role in regulating intestinal homeostasis and maintaining host health, face significant challenges in maintaining their survival rate after processing, storage, and oral administration, posing a substantial hurdle in probiotic use. In this study,…
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