Strategies and Mechanism in Reversing Intestinal Drug Efflux in Oral Drug Delivery

1. June 2022

Efflux transporters distributed at the apical side of human intestinal epithelial cells actively transport drugs from the enterocytes to the...

D-Alpha-Tocopheryl Poly(ethylene Glycol 1000) Succinate-Coated Manganese-Zinc Ferrite Nanomaterials for a Dual-Mode Magnetic Resonance Imaging Contrast Agent and Hyperthermia Treatments

16. May 2022

Manganese-zinc ferrite (MZF) is known as high-performance magnetic material and has been used in many fields and development. In the...

Osmolality of Excipients for Parenteral Formulation Measured by Freezing Point Depression and Vapor Pressure – A Comparative Analysis

27. April 2022

Purpose To investigate the difference in methods to determine the osmolality in solutions of stabilizers used for long-acting injectable suspensions....

Fast In Vitro Release and In Vivo Absorption of an Anti-Schizophrenic Drug Paliperidone from Its Soluplus®/TPGS Mixed Micelles

25. April 2022

The purpose of this study was to develop a drug delivery system for paliperidone (PPD) in order to provide a...

Reduction-sensitive mixed micelles based on mPEG-SS-PzLL /TPGS to enhance anticancer efficiency of doxorubicin

19. March 2022

Currently, the drawbacks of the chemotherapy drugs are still demonstrated poor water solubility, systemic toxicity and even multidrug resistance (MDR)...

Optimization of the Micellar-Based In Situ Gelling Systems Posaconazole with Quality by Design (QbD) Approach and Characterization by In Vitro Studies

4. March 2022

Background: Fungal ocular infections can cause serious consequences, despite their low incidence. It has been reported that Posaconazole (PSC) is...

Application of Vitamin E TPGS in ocular therapeutics – Attributes beyond excipient

11. February 2022

Diseases affecting the anterior segment and the external surface of the eye are usually treated by drugs applied topically. The...

Biological fate and interaction with cytochromes P450 of the nanocarrier material, D-α-tocopheryl polyethylene glycol 1000 succinate

2. February 2022

D-α-Tocopheryl polyethylene glycol 1000 succinate (TPGS, also known as vitamin E-TPGS) is a biodegradable amphiphilic polymer prepared by esterification of...

Formulation, optimization and evaluation of vitamin E TPGS emulsified dorzolamide solid lipid nanoparticles

9. January 2022

Herein, we designed this research to develop dorzolamide (DRZ) encapsulated solid lipid nanoparticles (SLNs) for ocular administration. The DRZ-SLNs were fabricated by ultrasonic emulsification...

A Customized Screening Tool Approach for the Development of a Self-Nanoemulsifying Drug Delivery System (SNEDDS)

2. January 2022

The present study focused on establishing a novel, (pre-)screening approach that enables the development of promising performing self-nanoemulsifying drug delivery...

PMC Isochem