Development and evaluation of TPGS/PVA-based nanosuspension for enhancing dissolution and oral bioavailability of ticagrelor

7. April 2020

In this study, we developed ticagrelor-dispersed nanosuspension (TCG-NSP) to enhance the dissolution and oral bioavailability of ticagrelor (TCG) through a...

Schematic representation of the different steps involved in the preparation of ASMP-Nano.

Assembling Surfactants-Mucoadhesive Polymer Nanomicelles (ASMP-Nano) for Ocular Delivery of Cyclosporine-A

20. March 2020

The physiological protective mechanisms of the eye reduce the bioavailability of topically administered drugs above all for those with high...

Design and Synthesis of Polymer Prodrugs for Improving Water-Solubility, Pharmacokinetic Behavior and Antitumor Efficacy of TXA9

20. March 2020

Purpose TXA9, a novel cardiac glycoside, has a potent anti-proliferative effect against A549 human lung cancer cells, however, possesses a...

A Comparative Study of the Effect of Different Stabilizers on the Critical Quality Attributes of Self-Assembling Nano Co-Crystals

3. March 2020

Lamivudine (3TC) and zidovudine (AZT) are antiviral agents used orally to manage HIV/AIDS infection. A pseudo one-solvent bottom-up approach was...

Vitamin E TPGS based transferosomes augmented TAT as a promising delivery system for improved transdermal delivery of raloxifene.

11. February 2020

Raloxifene is commonly used for breast cancer protection. The low bioavailability of raloxifene (2%) is the result of its low...

Schematic representation of method of preparation, dosage forms, components and applications of nanosuspensions in drug delivery systems

Emerging role of nanosuspensions in drug delivery systems

24. January 2020

Rapid advancement in drug discovery process is leading to a number of potential new drug candidates having excellent drug efficacy...

Old wine in new bottles: Advanced drug delivery systems for disulfiram-based cancer therapy

24. January 2020

Disulfiram (DSF) is an FDA-approved drug that has been repurposed for cancer treatment. It showed excellent anticancer efficacy in combination...

Co-encapsulation of Docetaxel and Thymoquinone in mPEG-DSPE-Vitamin E TPGS-Lipid nanocapsules for breast cancer therapy: Formulation Optimization and Implications on cellular and in vivo toxicity

16. January 2020

Rationally designed combination nano-therapy approaches have emerged as a promising strategy for resistant breast cancer treatment. This research reports the...

Design and Characterization of Cyclosporine A-Loaded Nanofibers for Enhanced Drug Dissolution

15. January 2020

Despite widespread use as an immunosuppressant, the therapeutic efficacy of the undecapeptide cyclosporine A (CyA) is compromised when given by...

Formulation of Ketoconazole Nanocrystal-Based Cryopellets

10. January 2020

Commercial development of nanosuspensions for oral drug delivery generally involves a drying step which aims to generate a stable product...

PMC Isochem