PMC Isochem

Rationally designed combination nano-therapy approaches have emerged as a promising strategy for resistant breast cancer treatment. This research reports the...

Despite widespread use as an immunosuppressant, the therapeutic efficacy of the undecapeptide cyclosporine A (CyA) is compromised when given by...

Commercial development of nanosuspensions for oral drug delivery generally involves a drying step which aims to generate a stable product...

Raloxifene is commonly used for breast cancer protection. The low bioavailability of raloxifene (2%) is the result of its low...

Esculetin, a natural coumarin derived from herbs, has shown different potential pharmacological activities. However, the poor aqueous solubility of esculetin...

Electrospinning (ES) was originally reported in 1899 and the technology has been used since for the fabrication of con- tinuous...

Background Methotrexate (MTX), a folate anti-metabolite, has been used widely in the treatment of plenty of malignancies. However, the clinical...

Aims Apelin and vitamin E have been proposed as signaling molecules, but their synergistic role is unknown. The aim of...

Most cancer disease can be treated by the parenteral anticancer delivery method. The intravenous route takes the wholly bioavailable, accurate...

The objective of the present study was to develop a solid dispersion formulation to improve oral bioavailability of poorly water-soluble...