Vitamin E TPGS based transferosomes augmented TAT as a promising delivery system for improved transdermal delivery of raloxifene

7. January 2020

Raloxifene is commonly used for breast cancer protection. The low bioavailability of raloxifene (2%) is the result of its low...

Design space approach in the development of esculetin nanocrystals by a small-scale wet-bead milling process

5. January 2020

Esculetin, a natural coumarin derived from herbs, has shown different potential pharmacological activities. However, the poor aqueous solubility of esculetin...

chematic drawing of single-needle electrospinning

Scale-up of electrospinning technology: Applications in the pharmaceutical industry

30. December 2019

Electrospinning (ES) was originally reported in 1899 and the technology has been used since for the fabrication of con- tinuous...

Ameliorated in vitro anticancer efficacy of methotrexate D-α-Tocopheryl polyethylene glycol 1000 succinate ester against breast cancer cells

29. December 2019

Background Methotrexate (MTX), a folate anti-metabolite, has been used widely in the treatment of plenty of malignancies. However, the clinical...

Different graphs about Vitamin E TPGS Apelin attenuates mitochondrial ROS production in H9C2 cells and cardiomyocytes

In vitro and in vivo cardioprotective and metabolic efficacy of vitamin E TPGS/Apelin

22. December 2019

Aims Apelin and vitamin E have been proposed as signaling molecules, but their synergistic role is unknown. The aim of...

In vitro and in vivo effects of SLN and NLC encapsulation of drugs

Solid lipid nanoparticles and nanostructured lipid carriers in oral cancer drug delivery

20. December 2019

Most cancer disease can be treated by the parenteral anticancer delivery method. The intravenous route takes the wholly bioavailable, accurate...

Carvedilol solid dispersion for enhanced oral bioavailability using rat model

15. December 2019

The objective of the present study was to develop a solid dispersion formulation to improve oral bioavailability of poorly water-soluble...

Successful development of oral SEDDS: screening of excipients from the industrial point of view

10. December 2019

Oral administration is the most accepted and favored route as various side effects such as fear, pain and risk of...

Nanocarrier mediated drug delivery systems for disulfiram

Recent advances in the delivery of disulfiram: a critical analysis of promising approaches to improve its pharmacokinetic profile and anticancer efficacy

2. December 2019

Background Disulfiram (DSF) has a long history of being used as a first-line promising therapy for treatment of alcoholism in...

Development Of Methamphetamine Abuse-Deterrent Formulations Using Sucrose Acetate Isobutyrate

Elucidating molecular design principles for charge-alternating peptides

27. November 2019

The therapeutic potential of protein drugs has been hindered by difficulties with long-term stability and rapid clearance from the body....

PMC Isochem