Pharma Excipients
Surfactants
Mechanistic Insight in Permeability through Different Membranes in the Presence of Pharmaceutical…
The present study reports the effects of two pharmaceutical excipients of differing natures—non-ionic surfactant pluronic F127 (F127) and anionic sulfobutylether-β-cyclodextrin (SBE-β-CD)—on the permeation of the model compound, carbamazepine (CBZ). The permeability coefficients of CBZ at three…
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Formulating Resveratrol and Melatonin Self-Nanoemulsifying Drug Delivery Systems (SNEDDS) for Ocular…
Recent studies have demonstrated that Sirtuin-1 (SIRT-1)-activating molecules exert a protective role in degenerative ocular diseases. However, these molecules hardly reach the back of the eye due to poor solubility in aqueous environments and low bioavailability after topical application on the…
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Addiction to Psychoactive Prescription Drugs: Can the Excipients of the Formulations Play a Role?
Abstract
In the development of drugs misuse and addiction, references are often made to the study of the API (active principle ingredient) as the main cause, which is certainly true, but there is a tendency to overlook the possible role of certain excipients which may be involved in the…
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Multilevel categoric factorial design for optimization of raloxifene hydrochloride solid dispersion…
Raloxifene Hydrochloride (RLH) is a selective estrogen receptor modulator (SERM) used for the treatment and prevention of postmenopausal osteoporosis. This Active Pharmaceutical Ingredient (API) belongs to class II biopharmaceutics classification system (BCS) hence it is characterized by…
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Lasmiditan Nanoemulsion Based In Situ Gel Intranasal Dosage Form: Formulation, Characterization And…
This study aimed to formulate lasmiditan (LAS) as a nanoemulsion in situ gel (NEIG) by utilising nanotechnology in order to escape the problems associated with the poor oral bioavailability of the drug. A study regarding the LAS solubility in different oils, surfactants and co-surfactants, was…
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Lecithin Microemulsions as Drug Carriers
The paper describes examples of microemulsions based on a well-known biocompatible surfactant, lecithin, and the possibilities of their use as drug carriers. The main problem encountered when developing lecithin microemulsions is the search for suitable cosurfactants. Molecules with short alkyl…
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Preparation, optimization and evaluation of Osthole transdermal therapeutic system
In the current study, the solubility and permeability of Osthole-loaded microemulsion were enhanced, which increased bioavailability. In addition, Carbomer 940 was added for prolonged drug delivery. The microemulsion was prepared after the screening of Kukui oil, Labrasol (surfactant), and…
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Engineering a novel water-in-oil biocompatible microemulsion system for the ocular delivery of…
Due to their unique characteristics, microemulsions (ME) represent one of the most promising delivery systems which can conquer poor ocular drug bioavailability providing long residence time. Development of a ME system, relying on the use of a safe and non-irritant surfactant combination derived…
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Leveraging spray drying technique for advancing biologic product development – A mini review
Over the last 15 years, spray drying (SD), as an alternative to lyophilization, to manufacture and increase the stability of biologics has demonstrated promising outcomes. Pharmaceutical companies, on the other hand, have yet to expand technology for the production of aseptic spray-dried biologics.…
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Nintedanib solid lipid nanoparticles improve oral bioavailability and ameliorate pulmonary fibrosis…
Nintedanib (NIN) and pirfenidone are the only approved drugs for the treatment of Idiopathic Pulmonary Fibrosis (IPF). However, NIN and pirfenidone have low oral bioavailability and limited therapeutic potential, requiring higher dosages to increase their efficacy, which causes significant liver and…
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