Browsing Tag

SMEDDS

Enhanced intestinal lymphatic absorption of saquinavir through supersaturated self-microemulsifying…

Feb 24, 2019

The therapeutic potential of saquinavir, a specific inhibitor of human immunodeficiency virus (HIV)-1 and HIV-2 protease enzymes, has been largely limited because of a low solubility and consequnt low bioavailability. Thus, we aimed to design a supersaturated self-microemulsifying drug delivery…
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Emulsifier

Colloidal aspects of dispersion and digestion of self-dispersing lipid-based formulations for poorly…

Jan 28, 2019

Self-dispersing lipid-based formulations, particularly self-microemulsifying drug delivery systems (SMEDDS) have gained an increased interest in recent times as a means to enhance the oral bioavailability of poorly water-soluble lipophilic drugs. Upon dilution, SMEDDS self-emulsify in an aqueous…
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Cellulose Ethers

Preparation of a solid self-microemulsifying drug delivery system by hot-melt extrusion

Oct 28, 2018

Hot-melt extrusion (HME) has gained increasing attention in the pharmaceutical industry; however, its potential in the preparation of solid self-emulsifying drug delivery systems (S-SMEDDS) is still unexplored. This study sought to prepare enteric S-SMEDDS by HME and evaluate the effects of the…
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