Browsing Tag

wet granulation

Novel population balance model for granule aggregation and breakage in fluidized bed granulation and…

Oct 24, 2018

A novel population balance model for the fluidized bed granulation and drying process was developed taking into consideration moisture content for determining the coalescence and breakage probabilities. Experimental data of pharmaceutical powders manufactured at production scale was used to…
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Binder

Use of Mannitol as a Filler in Wet Granulation

Oct 13, 2018

A study was conducted to evaluate mannitol as a filler along with microcrystalline cellulose (MCC) in wet granulated tablet formulation, in situations in which lactose cannot be included in the formulation because of chemical incompatibility with the active drug. A two-level full factorial design…
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Effect of Binder Attributes on Granule Growth and Densification

Oct 10, 2018

The rate and extent of granule growth and densification during high-shear wet granulation (HSWG) depends on a variety of formulation and process variables, including material attributes of critical formulation excipients, such as binders. The effects of known binder attributes to the rate and extent…
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Binder

Wet-granulation process: phenomenological analysis and process parameters optimization

Sep 26, 2018

Wet granulation is a size-enlargement process applied in many industrial fields, such as pharmaceutical, nutraceutical, zootecnichal, to improve flowability and compressibility properties of powders. In this work analysis of the particle size distribution (PSD) of granules was performed to…
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