TPGS

To improve the solubility and maintain the amorphous state of BCS Ⅳ drug by preparing surfactant solid dispersions, solid dispersions of curcumin (CUR) with TPGS and HPMC were prepared by solvent method. The synthesized solid dispersions were characterized by scanning electron microscopy, powder…
Read More...

It has been seventy years since a water-soluble version of vitamin E called tocophersolan (also known as TPGS) was produced; it was approved by USFDA in 1998 as an inactive ingredient. Drug formulation developers were initially intrigued by its surfactant qualities, and gradually it made its way…
Read More...

Formulations based on emulsions for enhancing hydrophobic and lipophilic drug delivery and its bioavailability have attracted a lot of interest. As potential therapeutic agents, they are integrated with inert oils, emulsions, surfactant solubility, liposomes, etc.; drug delivering systems that use…
Read More...

Immune ophthalmopathy is a collection of autoimmune eye diseases. Immunosuppressants are drugs that can inhibit the body’s immune response. Considering drug side effects such as hepatorenal toxicity and the unique structure of the eye, incorporating immunosuppressants into ophthalmic nanodrug…
Read More...

Drug resistance is considered a key reason behind the failure of therapeutic medications for several chronic diseases, including hypertension, cancer therapeutics, and antimicrobial agents. Among the strategies used to overcome drug resistance are therapeutic targeting of other factors involved in…
Read More...

In this research, we present a systematic analysis of events inside single phase region of a nonionic microemulsion (ME) during incorporation of water and α-tocopherol (AT, a hydrophobic payload). The formulation was developed using α-tocopherol polyethylene glycol succinate, ethanol and oleic acid,…
Read More...

See the fourth issue of Fuji Chemical Industries Technical Newsletter. It presents the preparation of vitamin E tablets with Fujicalin®  and a comparison with the other commercially available DCPAs. Vitamin E is a fat-soluble vitamin like A, D and K. It is oily on physical appearance and…
Read More...

Despite advances in targeted therapies and immunotherapy in lung cancer, chemotherapy remains the backbone of treatment in most patients at different stages of the disease. Inhaled chemotherapy is a promising strategy to target lung tumours and to limit the induced severe systemic toxicities.…
Read More...

Current study intended to prepare and evaluate phospholipid-based, mixed micelles (MMs) to improve the ocular delivery of posaconazole (POS), a broad-spectrum antifungal drug. For this, MMs based on egg phosphatidylcholine (EPC), as the main component, in combination with various bile salts (sodium…
Read More...

Microwave-induced in situ amorphization is a novel technology for preparing amorphous solid dispersions (ASDs) to address the challenges of their long-term physical stability and downstream processing. To date, only few types of dielectric materials have been reported for microwave-induced in situ …
Read More...