TPGS

Abstract Background A dihydrofolate reductase inhibitor, pyrimethamine has an emerging anticancer potential but is not well soluble in aqueous and...

Abstract Cataract progression is closely associated with oxidative stress and inflammatory activation, while effective non-surgical interventions remain limited. Aesculetin (AES)...

Abstract Cannabidiol (CBD) exhibits poor oral bioavailability (approximately 6%) due to low solubility and excessive first-pass metabolism, limiting its therapeutic...

Abstract Background/Objectives: Reactive oxygen species (ROS)-responsive polymeric drug conjugates (PDCs) can enable oxidative stress-triggered drug release, but their activation may...

Abstract The nanocrystalline suspensions (NCS) are aqueous colloidal dispersions susceptible to Ostwald ripening and particle aggregation during processing and storage....

Abstract Mucopolysaccharidosis type I (MPS-I) is a rare, multisystemic lysosomal storage disease (LSD) caused by mutations in the IDUA gene, which encodes...

Article by David Tisi, Senopsys LLC: The principle of dual sourcing excipients is well established in pharmaceutical development, and its importance...

Abstract Entacapone is a catechol-O-methyltransferase (COMT) inhibitor, widely used for the symptomatic treatment of Parkinson’s disease. However, it presents setbacks...

Abstract Purpose Cabazitaxel (CBZ) is a semi-synthetic anti-cancer drug and belongs to BCS class IV category with poor water solubility...

Abstract Hydroxypropyl methylcellulose acetate succinate (HPMCAS) is commonly used to develop amorphous solid dispersions (ASDs), but its use is mostly...