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TPGS
d-α-tocopheryl polyethylene glycol 1000 succinate surface scaffold polysarcosine based polymeric…
In this study, Enzalutamide (ENZ) loaded Poly Lactic-co-Glycolic Acid (PLGA) nanoparticles coated with polysarcosine and d-α-Tocopheryl polyethylene glycol 1000 succinate (TPGS) were prepared using a three-step modified nanoprecipitation method combined with self-assembly. A three-factor,…
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Nose-to Brain Delivery of Resveratrol, a Non-Invasive Method for the Treatment of Cerebral Ischemia
Abstract
Cerebral ischemia represents a particular condition among neurological diseases due to its high frequency, high associated mortality, and the permanent disability in patients that survive it. Numerous studies in animal models have demonstrated the protective properties of resveratrol…
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Inhaled dry powder liposomal azithromycin for treatment of chronic lower respiratory tract infection
A dry powder inhaled liposomal azithromycin formulation was developed for the treatment of chronic respiratory diseases such as cystic fibrosis and bronchiectasis. Key properties including liposome size, charge and encapsulation efficiency powder size, shape, glass transition temperature (Tg), water…
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Effect of Talc and Vitamin E TPGS on Manufacturability, Stability and Release Properties of…
This study was focused on one particular case of hot-melt coating with trilaurin – a solid medium-chain monoacid triglyceride. The challenge of using trilaurin as coating agent in melting-based processes is linked to its relatively low melting profile: 15.6°C (Tm,α), 35.1°C (Tm,β′) and 45.7°C…
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Nanocrystal-chitosan particles for intra-articular delivery of disease-modifying osteoarthritis…
Osteoarthritis is the most common chronic joint disease and a major health care concern due to the lack of efficient treatments. This is mainly related to the local and degenerative nature of this disease. Kartogenin was recently reported as a disease-modifying osteoarthritis drug that promotes…
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Chitosan film of thiolated TPGS-modified Au-Ag nanoparticles for combating multidrug-resistant…
The widely used vitamin-E based amphiphilic material, tocopheryl polyethylene glycol succinate (TPGS) is further improvised as redox-sensitive thiolated TPGS (TPGS-SH), which has been developed by attaching 4-aminothiophenol. Further, TPGS and TPGS-SH-coated bimetallic gold-silver nanoparticles…
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Multicompartmental pharmacokinetic evaluation of enavogliflozin eye drop formulation: Understanding…
Abstract
Purpose
Treating posterior segment diseases presents significant challenges because of the intricate anatomical and physiological barriers within the eye that limit drug penetration. Enavogliflozin eye drops (DWRX2008) are a novel candidate for diabetic retinopathy; however, their…
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TPGS/soluplus® blended micelles: an effective strategy for improving loading capacity of ferroptosis…
Erastin is the most classical small molecular ferroptosis inducer but its clinical application is hindered due to its poor solubility. Nanotechnology has been used to improve ferroptosis inducer erastin’s solubility. The recently reported erastin-incorporated nanosystems (e.g., nanoparticulate…
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Development of rapidly soluble mebendazole nanosuspension for colorectal cancer
Mebendazole (MBZ) has been proven as a repurposing molecule against colorectal cancer. Unfortunately, its clinical application is constrained by its extremely poor solubility and bioavailability. The aim of the current work was to augment the dissolution rate at colonic pH and the anticancer…
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Cyclosporine A micellar nasal spray characterization and antiviral action against SARS-CoV-2
The upper airways represent the point of entrance from where Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection spreads to the lungs. In the present work, α-tocopheryl-polyethylene-glycol succinate (TPGS) micelles loaded with cyclosporine A (CSA) were developed for nasal…
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