Pharma Excipients
Viscocity Agent
A new perspective for psoriasis: Dithranol nanosponge loaded hydrogels
We developed dithranol nanosponge integrated Carbopol hydrogel (DTHNS-HG) as a novel perspective for psoriasis management. Dithranol was chosen as antipsoriatic moiety for this system. In this study, our objective was to fabricate and evaluate DTHNS-HG for in vivo anti-psoriatic activity using mouse…
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Tadalafil Nanoemulsion Mists for Treatment of Pediatric Pulmonary Hypertension via Nebulization
Oral tadalafil (TD) proved promising in treating pediatric pulmonary arterial hypertension (PAH). However, to ensure higher efficacy and reduce the systemic side effects, targeted delivery to the lungs through nebulization was proposed as an alternative approach. This poorly soluble drug was…
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Effect of Combination of Carbopol-940 Base and HPMC Gel Extract of Aloe Vera Flesh on Physical…
Aloe vera (Aloe chinensis Barker.) has been shown to be efficacious as an antibacterial which has the potential to treat acne caused by the bacteria Propionibacterium acnes. The use of this combination can increase the viscosity, dissolution, diffusion, and bioavailability of the preparation. This…
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α-Cyclodextrin-based poly(pseudo)rotaxane for antifungal drug delivery to the vaginal mucosa
This work aimed to evaluate poly(pseudo)rotaxanes (PPRs) potential for vaginal antifungal delivery. For this, PPRs containing terbinafine (TB) 2 % were obtained using two small surfactants, Kolliphor® RH40 and Gelucire® 48/16, and different α-cyclodextrin (α-CD) concentrations (5 and 10 %). PPRs…
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Overcoming Challenges in Ophthalmic Formulations through Polymer Selection – A Closer Look at…
Ophthalmic drug formulations are growing in importance due to the increased prevalence of eye-related disorders such as diabetic retinopathy and macular degeneration.1 However, ocular drug delivery is challenging due to unique anatomical and physiological barriers such as pre-corneal loss factors…
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Days or Centuries? – Predicting the Shelf-Life of ASDS
PURPOSE
Amorphous solid dispersions (ASDs) are a state-of-the-art enabling formulation technique for poorly water-soluble drugs. Drug recrystallization in the polymer matrix highly unwanted: marks end of shelf life of such a formulation.
Overcoming the poorly understood drug recrystallization…
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Ophthalmics Process by Merck – Keep a close eye on quality and safety
Reduce risk and overcome challenges
Ophthalmic drugs pose special formulation challenges to manufacturers. In general, choosing the right processes and materials is important to ensure the required quality, drug tolerability and patient adherence. Formulators must pay attention to tonicity, pH,…
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Fabrication and Characterizations of Pharmaceutical Emulgel Co-Loaded with Naproxen-Eugenol for…
The aim of this study was to fabricate and characterize a pharmaceutical emulgel co-loaded with naproxen/eugenol for transdermal delivery to improve the analgesic and anti-inflammatory effects and to eliminate GIT adverse reactions. Emulgel was prepared using a slow emulsification method and…
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Technology development to evaluate the effectiveness of viscosity reducing excipients
Addition of pharmaceutical excipients is a commonly used approach to decrease the viscosity of highly concentrated protein formulations, which otherwise could not be subcutaneously injected or processed. The variety of protein–protein interactions, which are responsible for increased viscosities,…
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Poloxamer-Based Hydrogel as Drug Delivery System: How Polymeric Excipients Influence the…
Thermogelling amphiphilic block copolymers have been widely investigated in the development of pharmaceutical drug carriers. In particular, thermosensitive gels based on poloxamer 407 (P407) have great potential for periodontal disease treatment, thanks to their ability to be liquid at room…
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