Increasing Drug Solubility with Solid Dispersions of SilSol 6035 Silica Formulated Into Sublingual Tablets

Improving the solubility of BCS class 2 drugs is a continuing challenge for the pharmaceutical formulator. Improving solubility could allow for formulations using significantly less active and open the door to new dosage forms and avenues for lifecycle extensions. Creating solid dispersions are a promising way to improve drug solubility. Grace SilSol™6035 has a specifically engineered surface and pore distribution to enable stable amorphous dispersions by solvent deposition. Poorly soluble Nifedipine was loaded on SilSol 6035 silica to make a solid dispersion with enhanced water solubility Nifedipine is stabilized in its amorphous form by confinement effects of the engineered pore size of the silica. This solid dispersion greatly improves the solubility of Nifedipine and, since it is a free flowing powder, is easily formulated into solid oral dosage forms such as tablets.