The effects of improper mixing and preferential wetting of active and excipient ingredients on content uniformity in high shear wet granulation
Elsevier – Powder Technology – Available online 21 March 2015
This work focuses on the content non-homogeneity in granules across size classes in a high shear wet granulation process as a result of powder segregation during dry mixing coupled with preferential wettability of the one of the ingredients with the binder fluid…
http://www.sciencedirect.com/science/article/pii/S0032591015002132