Bioavailability enhancement

Abstract Background: Solid dispersions (SDs) of etodolac (ETD), a poorly water-soluble drug model, were developed to enhance its solubility and dissolution...

Abstract Vancomycin, a glycopeptide antibiotic, is typically administered intravenously (IV) for severe Gram-positive bacterial infections. While the oral route offers...

Abstract Introduction/Objectives Compounded pimobendan is prescribed without knowledge of the effect of excipients. The objective of this study was to...

Abstract Oral administration of solid dosage forms for delivery of therapeutic peptides is highly desired. Preclinical investigations on co-administration with...

WHY MANAGING VARIABILITY MATTERS? Pharmaceutical ingredients play a key role in drug formulation. Variations in their composition and physicochemical properties...

Abstract Ezetimibe is a cholesterol absorption inhibitor widely used in the treatment of dyslipidemia. However, its clinical efficacy is limited...

Abstract Amorphous solid dispersions (ASDs) represent a promising formulation strategy for improving the solubility and bioavailability of poorly water-soluble drugs,...

Abstract Lornoxicam, a potent nonsteroidal anti-inflammatory drug (NSAID), suffers from poor aqueous solubility, leading to limited dissolution and variable bioavailability....

Abstract Poor bioavailability and systemic toxicity restrict the oral administration of chemotherapeutic agents such as exemestane (EXM) and quercetin (QUR)....

Abstract Pulmonary delivery can deliver cannabidiol (CBD) with high bioavailability and fast onset of action. One formulation obstacle is the...