Bioavailability enhancement

Abstract Pramipexole dihydrochloride (PPX) is a Biopharmaceutical Classification System (BCS) Class I drug with a short half-life, and its aqueous...

Drug Delivery and Biomedical Applications of Porous Silicon-Based Nanocarriers See the new book, edited by Rajendra Awasthi, Santosh Kumar Singh,...

Abstract This study investigates the influence of phospholipid saturation by comparing hydrogenated soy phosphatidylcholine (HSPC) and egg yolk phosphatidylcholine (EPC)...

Abstract For any drug to be therapeutically efficacious it must enter the systemic circulation and in order to do so,...

Abstract Background: Solid dispersions (SDs) of etodolac (ETD), a poorly water-soluble drug model, were developed to enhance its solubility and dissolution...

Abstract Vancomycin, a glycopeptide antibiotic, is typically administered intravenously (IV) for severe Gram-positive bacterial infections. While the oral route offers...

Abstract Introduction/Objectives Compounded pimobendan is prescribed without knowledge of the effect of excipients. The objective of this study was to...

Abstract Oral administration of solid dosage forms for delivery of therapeutic peptides is highly desired. Preclinical investigations on co-administration with...

WHY MANAGING VARIABILITY MATTERS? Pharmaceutical ingredients play a key role in drug formulation. Variations in their composition and physicochemical properties...

Abstract Ezetimibe is a cholesterol absorption inhibitor widely used in the treatment of dyslipidemia. However, its clinical efficacy is limited...